Results 71 to 80 of about 120,483,411 (287)

Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice. [PDF]

PLoS ONE, 2016
Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-
Minchan Gil, Yun Kyu Kim, Sang Bum Hong, Kyung Jin Lee   +3 more
doaj   +1 more source

Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase [PDF]

, 2010
Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). Previously we have shown that mutations in human POR cause a rare form of congenital adrenal hyperplasia. In
Primus E. Mullis, Amit V. Pandey, Pandey, Amit V, Flück, Christa E, Christa E. Flück, Mullis, Primus-Eugen, Mullis PE, Pandey AV, Flück CE   +8 more
core   +1 more source

A Celastrol–Platinum(IV) Nanoprodrug Couples Ferroptosis With Caspase‐Independent Pyroptosis to Enhance Anti‐PD‐1 Therapy in Colorectal Cancer

Advanced Science, EarlyView.
CPAN integrates celastrol‐driven oxidative stress with Pt(IV)‐induced DNA damage to couple ferroptosis with caspase‐independent pyroptosis. Celastrol disrupts the GSH/GPX4 axis and promotes lipid peroxidation, while Pt(IV)‐associated PARP/PARylation signaling facilitates full‐length GSDME oligomerization.
Huirong Li, Wenxiang Feng, Le Xin, Wu Zhong, Zhuhuai Peng, Zhihong Ke, Wenbin Zhou, Yutong Wu, Ying Chen, Hongwei Wang, Jidong Liu, Jinjun Ye, Weihong Guo   +12 more
wiley   +1 more source

Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase‐1

FEBS Open Bio, 2022
Arabidopsis thaliana heme oxygenase‐1 (AtHO‐1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin‐related functions in plants.
Jia Wang, Xiaoyi Li, Jing‐Wen Chang, Tong Ye, Ying Mao, Xiao Wang, Lin Liu   +6 more
doaj   +1 more source

Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis

Antioxidants, 2021
Osteoarthritis (OA) is a common aging-associated disease that clinically manifests as joint pain, mobility limitations, and compromised quality of life.
Yohei Sanada, Sho Joseph Ozaki Tan, Nobuo Adachi, Shigeru Miyaki   +3 more
doaj   +1 more source

Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress

, 2008
Heme oxygenase-1 is the rate-limiting enzyme in the degradation of heme into biliverdin, carbon monoxide and free divalent iron. In this study, we cloned heme oxygenase isoform 1 (CaHO-1) from a hypoxia-tolerant teleost fish Carassius auratus.
Wang, Dan, Zhong, Xue-Ping, Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Qiao, Zhi-Xian, Gui, Jian-Fang   +4 more
core   +1 more source

Localized Hydrogen Release Driven by Mg–Pd Microgalvanic Cells from 3D‐Printed Microneedles Reverses Redox Homeostasis for Psoriasis Treatment

Advanced Science, EarlyView.
A 3D printing microneedle (MP‐MN), loading magnesium‐based micro‐galvanic cells (MP), is designed for improving psoriasis. H2 generated from MP‐MN scavenges ROS and •OH, actives NRF2‐KEAP1 pathway, and decreases inflammation, thereby effectively restoring the oxidative stress homeostasis of psoriatic skin and suppressing the excessive proliferation of ...
Xinyue Shao, Zongyan He, Ning Yang, Lixuan Yin, Xujie Sun, Jingtong Qi, Xiaolong Feng, Yihui Zhang, Yiran Liu, Zhengwei Huang, Tianqun Lang   +10 more
wiley   +1 more source

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source

Studying the Relationship Between Heme Oxygenase-1 and Dipeptidyl Peptidase-4 in Obese Patients

مجلة بغداد للعلوم
Obesity is considered a major risk factor for diabetes mellitus type 2; it exacerbates insulin resistance and promotes an inflammatory environment favorable to oxidative stress.
Mays Mohammed Abdullah, Fayhaa Muqdad Khaleel   +1 more
doaj   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source