Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells. [PDF]
Mol Med RepZhang H +6 more
europepmc +1 more source
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Experimental Physiology, EarlyView.Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi +9 more
wiley +1 more source
Investigating the causal association between heme oxygenase-1 and asthma: A bidirectional two-sample Mendelian randomization analysis in a European population. [PDF]
World Allergy Organ JLiu W +5 more
europepmc +1 more source
Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components
Modern Agriculture, Volume 3, Issue 1, June 2025.The regulatory network system of mTOR regulates lactose, milk fat, and milk protein. Milk is urgently needed for the strong development of the dairy industry to meet the growing demand and ensure that the nutritional needs of the world's population are met.
RongNuo Li +3 more
wiley +1 more source
Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy. [PDF]
Int J Mol SciSalloom RJ +4 more
europepmc +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.In short, this study found that BFO could protect DN mice against renal injury induced by a high‐fat diet combined with STZ. Its protective effect may depend on the Nrf2/HO‐1 signaling pathway. ABSTRACT Diabetic nephropathy (DN) is a common complication of diabetes mellitus, with oxidative stress playing a critical role in its development.
Lei Zhu +10 more
wiley +1 more source
Heme oxygenase-1 protects cells from replication stress. [PDF]
Redox BiolChudy P +17 more
europepmc +1 more source
Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
MedComm, Volume 6, Issue 5, May 2025.Molecular hydrogen, delivered through inhalation, hydrogen‐rich water, or hydrogen solution injection, reduces oxidative stress, regulates immune responses, facilitates cell repair, and alleviates inflammatory bowel disease (IBD) and intestinal injury.
Jiayi Jin +7 more
wiley +1 more source
Reduction in Renal Heme Oxygenase-1 Is Associated with an Aggravation of Kidney Injury in Shiga Toxin-Induced Murine Hemolytic-Uremic Syndrome. [PDF]
Toxins (Basel)Mestekemper AN +6 more
europepmc +1 more source
Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis +10 more
wiley +1 more source