Correction: The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome. [PDF]
Front Endocrinol (Lausanne)Wang Q +6 more
europepmc +1 more source
Move beyond free radical theory of aging
iMetaOmics, Volume 3, Issue 1, March 2026.Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley +1 more source
Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia. [PDF]
Front Mol NeurosciZou XY +8 more
europepmc +1 more source
Heme oxygenase-1 and anti-inflammatory M2 macrophages.
Archives of Biochemistry and Biophysics, 2014 Y. Naito, T. Takagi, Yasuki Higashimura
semanticscholar +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi +4 more
wiley +1 more source
Heme and immunity: The heme oxygenase dichotomy. [PDF]
J Inorg BiochemPerry M, Hamza I.
europepmc +1 more source
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.
Proceedings of the National Academy of Sciences of the United States of America, 1968 R. Tenhunen, H. Marver, R. Schmid
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From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management
JCC Plus, Volume 1, Issue 2, March 2026.Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi +7 more
wiley +1 more source
Evaluation of saliva and serum heme oxygenase, arylesterase and nuclear factor erythroid 2-related factor 2 levels in patients with stage III periodontitis: a cross sectional study. [PDF]
Clin Oral InvestigYildiz ZH, Ustaoğlu G, Avci E.
europepmc +1 more source
Reduced stress defense in heme oxygenase 1-deficient cells.
Proceedings of the National Academy of Sciences of the United States of America, 1997 Kenneth D. Poss, S. Tonegawa
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