Results 171 to 180 of about 133,631 (206)

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Notoginsenoside R1 Attenuates Cisplatin-Induced Ototoxicity by Inducing Heme Oxygenase-1 Expression and Suppressing Oxidative Stress. [PDF]

Int J Mol Sci
Lin YC, Ho YJ, Lin YY, Liao AH, Kuo CY, Chen HK, Chen HC, Wang CH, Shih CP.   +8 more
europepmc   +1 more source

Reactive Oxygen Species and Antioxidants in Wound Healing: Mechanisms and Therapeutic Potential

International Wound Journal, Volume 22, Issue 5, May 2025.
ABSTRACT Wound healing is a complex biological process encompassing haemostasis, inflammation, proliferation and matrix remodelling. Reactive oxygen species (ROS) play a pivotal role in regulating key events such as antimicrobial defence, platelet activation and angiogenesis.
Kelechi Ukaegbu, Edward Allen, Kathy K. H. Svoboda   +2 more
wiley   +1 more source

Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice. [PDF]

Cells
Vats R, Ungalara R, Dubey RK, Sundd P, Pradhan-Sundd T.   +4 more
europepmc   +1 more source

Hypoxia Disrupts Sex‐Specific Physiology and Gene Expression Leading to Decreased Fitness in the Estuarine Sea Anemone Nematostella vectensis

Molecular Ecology, Volume 34, Issue 9, May 2025.
ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass, Angela C. Ye, Cassidy N. Hemphill, Katelyn G. Jones, Anna G. Dworetzky, Katie L. Barott   +5 more
wiley   +1 more source

Quercetin Attenuates Acetaldehyde-Induced Cytotoxicity via the Heme Oxygenase-1-Dependent Antioxidant Mechanism in Hepatocytes. [PDF]

Int J Mol Sci
Li K, Kidawara M, Chen Q, Munemasa S, Murata Y, Nakamura T, Nakamura Y.   +6 more
europepmc   +1 more source

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging. [PDF]

Front Immunol
Kaszubowska L, Kaczor JJ, Karnia MJ, Foerster J, Kmieć Z.   +4 more
europepmc   +1 more source

Silymarin ameliorates diazinon-induced subacute nephrotoxicity in rats via the Keap1-Nrf2/heme oxygenase-1 signaling pathway. [PDF]

Forensic Toxicol
Fath EM, Bakery HH, El-Shawarby RM, Abosalem MES, Ibrahim SS, Ebrahim N, Hegazy AM.   +6 more
europepmc   +1 more source

The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice. [PDF]

Antioxidants (Basel)
Martínez-Martel I, Bai X, Kordikowski R, Leite-Panissi CRA, Pol O.   +4 more
europepmc   +1 more source

Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. [PDF]

J Cell Mol Med
Wang H, Siren J, Perttunen S, Immonen K, Chen YC, Narumanchi S, Kosonen R, Paavola J, Laine M, Tikkanen I, Lakkisto P.   +10 more
europepmc   +1 more source