Results 11 to 20 of about 133,631 (206)
Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023 A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi +5 more
wiley +2 more sources
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis
Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023 The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a 13C labelling strategy was found to be a powerful approach to interrogate the biotransformation and determine the precise function of the enzyme.
Andrew J. Devine +13 more
wiley +1 more source
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies. 5‐aminolevulinic acid (5‐ALA)‐PDT is of particular interest, as it uses the photosensitiser PpIX, naturally produced in the heme pathway, following 5‐ALA administration.
Maria Mastrangelopoulou +7 more
wiley +1 more source
Molecular and cellular paradigms of multidrug resistance in cancer
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya +6 more
wiley +1 more source
International Journal of Molecular Sciences, 2018 Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response ...
M. Nitti +5 more
semanticscholar +1 more source
The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases
International Journal of Molecular Sciences, 2019 Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.
Y. Kishimoto, K. Kondo, Y. Momiyama
semanticscholar +1 more source
Angewandte Chemie, EarlyView.Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok +11 more
wiley +2 more sources
Food Science &Nutrition, Volume 11, Issue 1, Page 39-56, January 2023., 2023 Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐inflammatory, and anti‐apoptotic properties, rutin is of interest for its potential protective effects against toxic agents. Rutin has potential therapeutic effectiveness against several toxicants, and its beneficial effects are more than likely mediated by its ...
Sohrab Rahmani +4 more
wiley +1 more source
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
J. Belcher +12 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 93-100, January 2023., 2023 Docking results showed Resveratroloside had the highest Vina score, indicating that it was the most active and might be employed as a lead molecule for further structural modification. The possible action process of TMA‐Lyase lead compound was described, which further affects the occurrence and development of CHD.
Jincai Li +3 more
wiley +1 more source