Results 11 to 20 of about 188,137 (274)

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1. [PDF]

Haematologica, 2015
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Chakravorty, Subarna, Cunnington, Aubrey J, De La Fuente, Josu, Evans, Ceri, Horvath, Erzsebet, Levin, Michael, Orf, Katharine   +6 more
core   +5 more sources

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

Antioxidants, 2022
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin reductase (BVR).
S. Ryter
semanticscholar   +1 more source

Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders

Antioxidants, 2022
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin.
Yi‐Hsuan Wu, H. Hsieh
semanticscholar   +1 more source

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

Biomolecules, 2021
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli, V. Sorrenti, Salvo Grosso, L. Vanella   +3 more
semanticscholar   +1 more source

The Diverse Roles of Heme Oxygenase-1 in Tumor Progression

Frontiers in Immunology, 2021
Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
Kim Ngan Luu Hoang, Joanne E. Anstee, J. N. Arnold   +2 more
semanticscholar   +1 more source

Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease.

Blood, 2021
Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon, Jing Liu, H. Tsai, Lin Zeng, Seungjeong Yang, Aarti H Asnani, Jonghan Kim   +6 more
semanticscholar   +1 more source

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Antioxidants, 2020
SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and show lung injury and hemolysis.
F. Wagener, P. Pickkers, S. Peterson, S. Immenschuh, N. Abraham   +4 more
semanticscholar   +1 more source

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]

, 2016
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya, Dalman, Ronald L, Deng, Alicia C, Hsu, Mark, Kalish, Flora, Kayama, Yosuke, Maegdefessel, Lars, Morisawa, Takeshi, Spin, Joshua M, Stevenson, David K, Tsao, Philip S, Wallenstein, Matthew B, Wong, Ronald J, Zhao, Hui   +13 more
core   +8 more sources

Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide [PDF]

, 2011
Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling.
A. Caillon, B. Toutain, D. Henrion, D. Lambert, L. Loufrani, M.L. Freidja, V. Desquiret-Dumas, V. Procaccio   +7 more
core   +3 more sources

Heme oxygenase-1 as a modulator of intestinal inflammation development and progression [PDF]

, 2018
Indexación: Scopus.Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450.
Alexis M. Kalergis, Alexis M. Kalergis, Bárbara M. Schultz, Claudia A. Riedel, Geraldyne A. Salazar, Irenice Coronado-Arrázola, Loni Berkowitz, Loni Berkowitz, Manuel M. Álvarez-Lobos, Manuel M. Álvarez-Lobos, Omar P. Vallejos, Susan M. Bueno, Valentina P. Sebastián   +12 more
core   +2 more sources