Results 31 to 40 of about 85,853 (215)
Heme oxygenase in pregnancy and preeclampsia [PDF]
Current Opinion in Nephrology and Hypertension, 2013 Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field.New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that the heme oxygenase system is an ...
Eric M. George, Joey P. Granger
openaire +3 more sources
Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway [PDF]
, 2016 Circulating levels of chylomicron remnants (CMRs) increase postprandially and their composition directly reflects dietary lipid intake. These TG-rich lipoproteins likely contribute to the development of endothelial dysfunction, albeit via unknown ...
Botham, K M +3 more
core +1 more source
Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways [PDF]
Antioxidants, 2019 The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly attributed to excessive product formation. Underrated so far is,
J. Catharina Duvigneau +2 more
openaire +4 more sources
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John +5 more
wiley +1 more source
Protective Effects of Ellagic Acid Against Arsenic-Induced Hepatotoxicity in Male Wistar Rats: Impact of Heme Oxygenase-1 Upregulation. [PDF]
Food Sci NutrArsenic (As), a widespread environmental toxic substance, one of arsenic's clinical signs is liver damage. Ellagic acid protects liver toxicity as well as injuries induced by arsenic, and up‐regulates HO‐1 expression. Ellagic acid has a pharmacological characteristic, including anti‐inflammatory and antioxidant properties.
Alkully T, El-Refaei MF, Abdallah EAA.
europepmc +2 more sources
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan +13 more
wiley +1 more source
Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]
, 2015 Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Petrillo, Sara +10 more
core +5 more sources
A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. [PDF]
, 2015 Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation.
Borsani, Elisa +7 more
core +1 more source
Curcumin and Heme Oxygenase: Neuroprotection and Beyond [PDF]
International Journal of Molecular Sciences, 2019 Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti ...
Emanuela Mhillaj +5 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source