Results 31 to 40 of about 60,693 (303)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2020
We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj   +1 more source

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Hemin as a protective agent in an in vitro model of hypoxia/reoxygenation-induced injury

SAGE Open Medicine
Objective: Ischemia-reperfusion injury exacerbates myocardial damage and affects the prognosis of patients with ST-elevation myocardial infarction. This study investigates the potential cytoprotective effects of hemin in an in vitro cardiomyocyte model ...
Zuoyan Wang, Wei Liu
doaj   +1 more source

Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?

Biomolecules, 2020
Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (
Daniela Corona, Burcin Ekser, Rossella Gioco, Massimo Caruso, Chiara Schipa, Pierfrancesco Veroux, Alessia Giaquinta, Antonio Granata, Massimiliano Veroux   +8 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Systemic hemin therapy attenuates blood–brain barrier disruption after intracerebral hemorrhage

Neurobiology of Disease, 2014
Injury to the blood–brain barrier (BBB) is a key feature of intracerebral hemorrhage (ICH) and may contribute to perihematomal cell injury. Pretreatment with the heme oxygenase (HO)-1 inducer hemin improves barrier function and neurological outcome in ...
Xiangping Lu, Jing Chen-Roetling, Raymond F. Regan   +2 more
doaj   +1 more source

Heme oxygenase-1 in osteosarcoma

Journal of Cancer Research and Therapeutics, 2020
The present study was planned to analyze serum heme oxygenase-1 levels in osteosarcoma patients.Twenty five histopathologically confirmed cases of osteosarcoma localized without metastasis of all the ages attending the Orthopedic Clinics were included in the study group and twenty five patients having musculoskeletal pain (age and sex matched) served ...
Simmi, Kharb, M, Halder, Z S, Kundu
openaire   +2 more sources