Results 41 to 50 of about 133,631 (206)
Glia, Volume 71, Issue 2, Page 377-390, February 2023., 2023 Main Points Aging‐related morphological changes in microglia (dystrophy) do not correlate with expression of universal senescence markers. Microglial dystrophy coincides with an aging‐related increase in microglial ferritin expression. Abstract Aging can cause morphological transformation in human microglia indicative of cell senescence, termed ...
Pauline Neumann +3 more
wiley +1 more source
Ultrafast carbon monoxide photolysis and heme spin-crossover in myoglobin via nonadiabatic quantum dynamics [PDF]
Nature Communications 9, 4502 (2018), 2017 Light absorption of myoglobin triggers diatomic ligand photolysis and spin crossover transition of iron(II) that initiate protein conformational change. The photolysis and spin crossover reactions happen concurrently on a femtosecond timescale. The microscopic origin of these reactions remains controversial.
arxiv +1 more source
Circulation Research, 2016 Understanding the processes governing the ability of the heart to repair and regenerate after injury is crucial for developing translational medical solutions.
L. Otterbein, R. Foresti, R. Motterlini
semanticscholar +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Towards visible soliton microcomb generation [PDF]
Nature Communications 8, 1295 (2017), 2017 Frequency combs have applications that extend from the ultra-violet into the mid-infrared bands. Microcombs, a miniature and often semiconductor-chip-based device, can potentially access most of these applications, but are currently more limited in spectral reach.
arxiv +1 more source
Heme Oxygenase-1 in Kidney Health and Disease.
Antioxidants and Redox Signaling, 2016 SIGNIFICANCE Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a considerable burden in healthcare. The heme oxygenase (HO) system plays an important role in regulating oxidative stress and is protective in a variety of human and ...
J. Lever +3 more
semanticscholar +1 more source
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
OncoTarget, 2015 The oncogenic RAS-selective lethal small molecule Erastin triggers a unique iron-dependent form of nonapoptotic cell death termed ferroptosis. Ferroptosis is dependent upon the production of intracellular iron-dependent reactive oxygen species (ROS), but
Min‐Young Kwon +3 more
semanticscholar +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1213-1223, December 2022., 2022 Abstract Cerebral hemorrhage is a fatal disease that causes severe damage to local nerve function. The purpose of this research is to analyze the effect of kurarinone on hemin‐induced neuroinflammation and neurotoxicity. In our study, according to the results of bioinformatics analysis, we hypothesized that kurarinone might modulate cerebral hemorrhage
Zeng‐Qiang Jia +2 more
wiley +1 more source
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
Journal of Clinical Investigation, 2015 The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR ...
Souvik Dey +11 more
semanticscholar +1 more source
Angewandte Chemie International Edition, Accepted Article.The α‐methylene‐γ‐butyrolactone tulipalin A, a defense compound found in tulips, can polymerize via addition at the vinyl group or via ring‐opening polymerization, making it a highly promising monomer for bio‐based polymers. Since the biosynthesis of tulipalin A in plants remains elusive, we propose an alternative pathway for its synthesis starting ...
Andrea Nigl +11 more
wiley +1 more source