Results 71 to 80 of about 133,631 (206)
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.
Brain : a journal of neurology, 2014 The chemokine fractalkine modulates microglial responses in neurodegenerative diseases, including tauopathies, but the mechanistic processes and their relevance in human brain pathologies is not yet known.
I. Lastres-Becker +6 more
semanticscholar +1 more source
Pioneering Women Shaping the Field of Biocatalysis
ChemCatChem, EarlyView.Groundbreaking works of women scientists in biocatalysis are highlighted in this article. Their innovative contributions are categorized in four interrelated research areas, collectively driving advancements in enzymatic biotransformations. Abstract In this perspective article, we celebrate the accomplishments of female‐led research groups in ...
Ana I. Benítez‐Mateos +3 more
wiley +1 more source
Signaling function of heme oxygenase proteins.
Antioxidants and Redox Signaling, 2014 SIGNIFICANCE Many reports have underscored the importance of the heme degradation pathway that is regulated by heme oxygenase (HO). This reaction releases bile pigments and carbon monoxide (CO), which are important antioxidant and signaling molecules ...
P. Dennery
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.Depending on the pendant atom present in the N‐alkylated cyclam (1,4,8,11‐tetraazacyclotetradecane) based ligand framework, substantially altered conformations of the non‐heme iron(IV)‐oxo intermediates are revealed. Abstract The effect of a pendant neutral alcohol moiety in the N‐alkylated cyclam (1,4,8,11‐tetraazacyclotetradecane) ligand backbone is ...
Dibya Jyoti Barman +6 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, Volume 27, Issue 1, Page 12-18, February 2023., 2023 Abstract Patients with end‐stage renal disease (ESRD) have significantly lower survival rates compared with the general population of the same age. Peritoneal dialysis (PD) is an effective treatment for patients with ESRD, but the clinical outcome of PD patients is still not promising.
Xiyu Song +4 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Heme oxygenase (HO) is a key enzyme for heme degradation that is deeply involved in iron homeostasis, defensive reaction against oxidative stress, and signal transduction mediated by carbon monoxide.
M. Sugishima +6 more
semanticscholar +1 more source
Off-resonant coherent electron transport over three nanometers in multi-heme protein bioelectronic junctions [PDF]
arXiv, 2020 Multi-heme cytochromes (MHC) are fascinating proteins used by bacterial organisms to shuttle electrons within and between their cells. When placed in a solid state electronic junction, they support temperature-independent currents over several nanometers that are three orders of magnitude higher compared to other redox proteins of comparable size.
arxiv
Heme oxygenase-1 and acute kidney injury
Current opinion in nephrology and hypertension, 2014 Purpose of review Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide.
K. Nath
semanticscholar +1 more source
The efficacy of PDE5 inhibitors in diabetic patients
Andrology, Volume 11, Issue 2, Page 245-256, February 2023., 2023 Abstract Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first‐line therapeutic option.
Agnieszka Swiecicka
wiley +1 more source
ChemSusChem, EarlyView.An artificial enzymatic cascade to access natural vanillin from eugenol/clove oil was developed by revisiting the very first vanillin synthetic process from 19th century. The biosynthetic route consists of just two biocatalysts used as cell‐free preparation and molecular oxygen as oxidizing agent, outperforming also the natural microbial pathway which ...
Elisa Lanfranchi +12 more
wiley +1 more source