Results 71 to 80 of about 85,853 (215)

Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system [PDF]

, 2014
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors.
Choi, Marcelo Roberto, Della Penna, S. L., Fernandez, Belisario Enrique, Kouyoumdzian, Nicolás Martín, Kravetz, Maria Cecilia, Roson, Maria Ines, Rukavina Mikusic, Natalia Lucía   +6 more
core   +3 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease [PDF]

, 2013
The objective is to evaluate the effect of heme oxygenase-1 (HO-1) enzyme inducer and inhibitor on Mesenchymal Stem Cells (MSCs) in Alzheimer disease. Materials and Methods: 70 female albino rats were divided equally into 7 groups as follows: group 1 ...
Abdel Aziz, M. T., Abdel Raouf, E. R., Ahmed, H. H., ALKaffas, M. A., Atta, H. M., Rashed, L. A., Sabry, D., Samer, H.   +7 more
core  

The non-canonical functions of the heme oxygenases

Oncotarget, 2016
Heme oxygenase (HO) isoforms catalyze the conversion of heme to carbon monoxide (CO) and biliverdin with a concurrent release of iron, which can drive the synthesis of ferritin for iron sequestration. Most of the studies so far were directed at evaluating the protective effect of these enzymes because of their ability to generate antioxidant and ...
VANELLA, LUCA, BARBAGALLO, IGNAZIO ALBERTO, Tibullo D, Forte S, ZAPPALA', AGATA, LI VOLTI, Giovanni   +5 more
openaire   +5 more sources

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

THE ROLE OF HEME OXYGENASE AND HSP70 IN TRAUMA

Euromediterranean Biomedical Journal, 2015
The so called Heat-shock proteins (Hsp) are the product of different genes induced by a sudden and/or short-lasting temperature elevation. However, the term Hsp is gene-rally used with great flexibility to indicate proteins induced also by other stressors be-sides heat shock.
Murabito P., Giarratano A., Astuto M., RAINERI, MARCO, Li Volti G.   +4 more
openaire   +3 more sources

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

The Fate of Iron Released from Heme by Hemeoxygenase-1 [PDF]

, 2006
A strain of Escherichia coli was genetically modified to co-express human heme oxygenase-1 and ferritin. The E. coli were then grown with varying amounts of hemin to see if the iron released upon degradation of the hemin by heme oxygenase-1 is loaded ...
Gardner, Jonathan Mark
core   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

Fluctuations and Changes in Acute Phase Reactive Proteins in Fasting and Nonfasting States

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigated the clinical changes in acute‐phase reactive protein (APRPs) assays under fasting and nonfasting conditions. The findings revealed significant fluctuations in APRPs levels at different intervals following a standardized diet. Specifically, clinical bias for serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), procalcitonin (PCT)
Ben Huang, Shuxian Miao, Yan Xu, Si‐Jie Qiu, Rui‐Xia Yang, Hua‐Guo Xu   +5 more
wiley   +1 more source