Results 81 to 90 of about 133,631 (206)

Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 83-97, January 2023., 2023
Abstract Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet‐induced obesity.
Bendik C. Brinchmann, Jørn A. Holme, Nadine Frerker, Mia H. Rambøl, Tommy Karlsen, Jan E. Brinchmann, Alena Kubátová, Klara Kukowski, Tonje Skuland, Johan Øvrevik   +9 more
wiley   +1 more source

Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons [PDF]

Biochemistry (American Chemical Society) 45 (2006) 12380-12391, 2009
In Sphingomonas CHY-1, a single ring-hydroxylating dioxygenase is responsible for the initial attack of a range of polycyclic aromatic hydrocarbons (PAHs) composed of up to five rings. The components of this enzyme were separately purified and characterized. The oxygenase component (ht-PhnI) was shown to contain one Rieske-type [2Fe-2S] cluster and one
arxiv  

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Moderate hyperuricaemia ameliorated kidney damage in a low‐renin model of experimental renal insufficiency

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 21-32, January 2023., 2023
Abstract Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricaemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham operation, the rats were allocated
Venla Kurra, Arttu Eräranta, Timo Paavonen, Teemu Honkanen, Juhani Myllymäki, Asko Riutta, Ilkka Tikkanen, Päivi Lakkisto, Jukka Mustonen, Ilkka Pörsti   +9 more
wiley   +1 more source

Investigating electron conductivity regimes in the bacterial cytochrome wire OmcS [PDF]

arXiv
The anaerobic bacterium \textit{Geobacter sulfurreducens} produces extracellular, electronically conductive cytochrome polymer wires that are conductive over micron length scales. Structure models from cryo-electron microscopy data show OmcS wires form a linear chain of hemes along the protein wire axis, which is proposed as the structural basis ...
arxiv  

Deep Kinship Verification via Appearance-shape Joint Prediction and Adaptation-based Approach [PDF]

arXiv, 2019
Kinship verification aims to identify the kin relation between two given face images. It is a very challenging problem due to the lack of training data and facial similarity variations between kinship pairs. In this work, we build a novel appearance and shape based deep learning pipeline.
arxiv  

Heme oxygenase-1: a metabolic nike.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. RECENT ADVANCES The heme oxygenases (HO) are metabolic enzymes that
B. Wegiel, Zsuzsanna Nemeth, Matheus Correa-Costa, A. Bulmer, L. Otterbein   +4 more
semanticscholar   +1 more source

Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy

Exploration, EarlyView.
Self‐assembled S‐Cu(I)‐S sites were spatially isolated onto a two‐dimensional Ti3C2 surface to produce a structurally well‐defined and highly functional single‐site copper(I) nanomodulator CuNTD, which can induce severe immunogenic cell death through multiple regulatory pathways of synergistic cascade photothermal‐amplified ROS storms, cuproptosis and ...
Yuanyuan Zhang, Shengnan Ya, Jingnan Huang, Yangyang Ju, Xueyang Fang, Xinteng Ouyang, Qingdong Zeng, Xinyao Zhou, Xiyun Yan, Guohui Nie, Kelong Fan, Bin Zhang   +11 more
wiley   +1 more source

Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis–Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 2, Page 197-210, February 2023., 2023
Abstract Chronic intraperitoneal injection of thioacetamide (TAA) in rats has been used as an animal model of human cirrhosis to study the effects of the disease on drug metabolism. However, TAA inhibits P450 enzymes directly and independently of cirrhosis. We investigated the effects of chronic cirrhosis in rats, induced by 10 weeks of intraperitoneal
Devaraj Venkatapura Chandrashekar, Barent N. DuBois, Mamunur Rashid, Reza Mehvar   +3 more
wiley   +1 more source

Simulation of Heme using DFT+U: a step toward accurate spin-state energetics [PDF]

arXiv, 2007
We investigate the DFT+U approach as a viable solution to describe the low-lying states of ligated and unligated iron heme complexes. Besides their central role in organometallic chemistry, these compounds represent a paradigmatic case where LDA, GGA, and common hybrid functionals fail to reproduce the experimental magnetic splittings.
arxiv