Results 1 to 10 of about 51,101 (114)

Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology [PDF]

Frontiers in Immunology
Although the pathological significance of myeloid cell heterogeneity is still poorly understood, new evidence indicates that distinct macrophage subsets are characterized by specific metabolic programs that influence disease onset and progression. Within
Francesca Maria Consonni, Francesca Maria Consonni, Martina Incerti, Martina Incerti, Milena Bertolotti, Giulia Ballerini, Giulia Ballerini, Valentina Garlatti, Valentina Garlatti, Antonio Sica, Antonio Sica   +10 more
doaj   +2 more sources

Heme oxygenase-1: potential therapeutic targets for periodontitis [PDF]

PeerJ
Periodontitis is one of the most prevalent inflammatory disease worldwide, which affects 11% of the global population and is a major cause of tooth loss.
Weiwei Lv, Shichen Hu, Fei Yang, Dong Lin, Haodong Zou, Wanyan Zhang, Qin Yang, Lihua Li, Xiaowen Chen, Yan Wu   +9 more
doaj   +3 more sources

Heme oxygenase-1 protects cells from replication stress [PDF]

Redox Biology
Heme oxygenase-1 (HO-1, HMOX1) degrades heme protecting cells from heme-induced oxidative damage. Beyond its well-established cellular functions, heme has emerged as a stabilizer of G-quadruplexes.
Patryk Chudy, Jakub Kochan, Mateusz Wawro, Phu Nguyen, Monika Gorczyca, Aliaksandra Varanko, Aleksandra Retka, Swati Sweta Ghadei, Emilija Napieralska, Anna Grochot-Przęczek, Krzysztof Szade, Lea-Sophie Berendes, Julien Park, Grzegorz Sokołowski, Qiuliyang Yu, Alicja Józkowicz, Witold N. Nowak, Wojciech Krzeptowski   +17 more
doaj   +2 more sources

Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2

Antioxidants, 2023
Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson, Hendrik J. Vreman, Ronald J. Wong   +2 more
doaj   +1 more source

Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]

PLoS ONE, 2013
The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer, Christoph Sponholz, Monique Slaba, Bianka Wissuwa, Ralf A Claus, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer   +8 more
doaj   +1 more source

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Haematologica, 2012
Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin.
Yehonatan Gottlieb, Marianna Truman, Lyora A. Cohen, Yael Leichtmann-Bardoogo, Esther G. Meyron-Holtz   +4 more
doaj   +1 more source

Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus

Frontiers in Cellular Neuroscience, 2020
Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár, Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Shahaf Levin, Alemeh Zamani, Radim Jančálek, Radim Jančálek, Petr Dubový, Marek Joukal   +10 more
doaj   +1 more source

Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes

Gynecology Obstetrics & Reproductive Medicine, 2022
OBJECTIVE: To examine early pregnancy levels of serum heme oxygenase-1, soluble vascular endothelial growth factor receptor-1, B-cell lymphoma/leukemia-2 in relation to unfavorable pregnancy outcomes, including preeclampsia, fetal growth restriction ...
Havva Sutcu, G. Fusun Varol, Cihan Inan, Isil Uzun, N.Cenk Sayin   +4 more
doaj   +1 more source

How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]

PLoS ONE, 2015
Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta, Jacob M Mattingly, Chi Li, John W Eaton   +3 more
doaj   +1 more source

Clinical Significance of Heme Oxygenase 1 in Tumor Progression

Antioxidants, 2021
Heme oxygenase 1 (HO-1) plays a key role in cell adaptation to stressors through the antioxidant, antiapoptotic, and anti-inflammatory properties of its metabolic products.
Mariapaola Nitti, Caterina Ivaldo, Nicola Traverso, Anna Lisa Furfaro   +3 more
doaj   +1 more source