Results 111 to 120 of about 29,780,783 (252)
Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction
, 2000 Bilirubin is a potent antioxidant generated intracellularly during the degradation of heme by the enzyme heme oxygenase. The purpose of this study was to determine the role of increased cardiac bilirubin in protection against postischemic myocardial ...
Roberto Motterlini +5 more
core +1 more source
Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling
Phytotherapy Research, EarlyView.Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf +2 more
wiley +1 more source
Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis
Phytotherapy Research, EarlyView.BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo +11 more
wiley +1 more source
Cellular Iron Depletion Weakens Induction of Heme Oxygenase-1 by Cadmium [PDF]
, 2011 Heme oxygenase-1 is an inducible cytoprotective gene, although its induction by environmental factors is not completely understood. This study aimed to ascertain if specific nutritive factors or related compounds influence heme oxygenase-1 expression. In
Loo, George +2 more
core
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Heme oxygenase, steering dioxygen activation toward heme hydroxylation
, 2005 The activation of dioxygen by heme oxygenase proceeds via formation of an obligatory ferric hydroperoxide intermediate (FeIII-OOH), as is the case in the activation of dioxygen by monooxygenase enzymes. This review summarizes current understanding of the
Zeng, Yuhong, Rivera, Mario
core +1 more source
Phytotherapy Research, EarlyView.Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang +10 more
wiley +1 more source
Biochemical properties and bioactivities of carbon monoxide-releasing molecules (CO-RMs). [PDF]
, 2006 Carbon monoxide (CO), synonymous of the "silent killer", is rapidly emerging as an important and versatile mediator of physiological processes. The study of CO has been hampered by the lack of a means to simulate its release biologically.
Sawle, P.J., Sawle, Philip John
core
, 2005 Heme oxygenases cleave the pro-oxidant heme molecule into carbon monoxide, ferrous iron, and biliverdin, which is subsequently converted to bilirubin.
Schlitt, Hans J. +7 more
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source