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Heme oxygenase-1 in organ transplantation
Frontiers in Bioscience, 2007Cells have a plethora of defense mechanisms that are activated upon exposure to oxidative stress. These aim at limiting the deleterious effects of oxidative stress and re-establishing homeostasis. In the particular context of organ transplantation, these defense mechanisms contribute to sustain graft survival via at least two interrelated mechanisms ...
Miguel P, Soares, Fritz H, Bach
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Heme Oxygenase-1 in Lung Disease
Current Drug Targets, 2010The lungs are a major target for various inflammatory, oxidative, carcinogenic or infectious stressors, which result in a range of lung diseases. Induction of heme oxygenase-1 (HO-1) during acute and chronic lung processes is a crucial defense mechanism.
Chintan M, Raval, Patty J, Lee
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Heme oxygenase-1: unleashing the protective properties of heme
Trends in Immunology, 2003Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein). HO-1 serves as a "protective" gene by virtue of the anti-inflammatory, anti-apoptotic and anti-proliferative actions of one or more of ...
Leo E, Otterbein +3 more
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2002
Transplantation is considered one of the most effective ways to overcome terminal dysfunction and failure of some organs. By transplanting organs or tissues between two genetically distinct individuals, an immune mediated response is triggered in the transplant recipient that evokes a potent inflammatory reaction, causing cell injury/death and leading ...
P. O. Berberat +4 more
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Transplantation is considered one of the most effective ways to overcome terminal dysfunction and failure of some organs. By transplanting organs or tissues between two genetically distinct individuals, an immune mediated response is triggered in the transplant recipient that evokes a potent inflammatory reaction, causing cell injury/death and leading ...
P. O. Berberat +4 more
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Immunoregulatory Properties of Heme Oxygenase-1
2010Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory ...
Blancou, Philippe +6 more
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Heme Oxygenase-1 and Transplantation Tolerance
Human Immunology, 2006Tolerance is the ultimate goal of transplantation: the lack of any need for immunosuppression with long-term survival of the transplanted tissue and a full immunological response to all antigens other than those on the transplant. In honor of my dear friend and colleague, Prof. Dr. Jon van Rood, I summarize here our work in this area making use of heme
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2019
A 26-month-old boy was admitted because of recurrent fever, generalized erythematous rash, and joint pain. The fever persisted, and the joint pain waxed and waned. The combination of fever, erythematous rash, and joint pain suggested that the patient suffered from a childhood chronic inflammatory illness such as systemic juvenile idiopathic arthritis ...
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A 26-month-old boy was admitted because of recurrent fever, generalized erythematous rash, and joint pain. The fever persisted, and the joint pain waxed and waned. The combination of fever, erythematous rash, and joint pain suggested that the patient suffered from a childhood chronic inflammatory illness such as systemic juvenile idiopathic arthritis ...
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Heme-oxygenase-1: Versatile Sentinel Against Injury
Journal of Molecular and Cellular Cardiology, 2002Heme oxygenase-1 (HO-1, also known as HSP32) catalyzes the conversion of heme into biliverdin IXa, carbon monoxide (CO) and iron. HO-2, derived from an entirely different gene, also catalyzes this reaction, but is regulated differently. HO-2 is constitutively expressed with little change in the amount of the protein, except with glucocorticoid ...
R N M, Cornelussen, A A, Knowlton
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Heme Oxygenase-1 and Transplantation
2004The discovery of nitric oxide (NO) in 1987 unraveled the novel concept that an endogenous production of a gaseous substance such as NO can impart diverse and critical functional effects on a wide spectrum of biological and pathological processes. These investigations have led to numerous fruitful discoveries, enhancing our understanding of many disease
Patty J. Lee +2 more
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