Results 51 to 60 of about 51,151 (156)
Frontiers in Neurology, 2018 Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage.
Qian-Qian Li +4 more
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Pharmacological and Clinical Significance of Heme Oxygenase-1
Antioxidants, 2021 This Special Issue collates and updates the current knowledge of the pharmacology and clinical applications concerning the enzyme heme oxygenase (HO) [...]
David E. Stec, Nader G. Abraham
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Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury
Neurobiology of Disease, 2007 In prior studies, we have observed that HO activity protects astrocytes from heme-mediated injury, but paradoxically increases neuronal injury. In this study, we tested the hypothesis that an adenovirus encoding the human HO-1 gene driven by an enhanced ...
Luna Benvenisti-Zarom, Raymond F. Regan
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Haematologica, 2011 Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano +10 more
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Biomedical and Biotechnology Research Journal, 2019 Background: Human immunodeficiency virus (HIV) infection is an important infection seen worldwide. HIV-infected patients usually have impaired immune function and get infected with other concurrent infections.
Won Sriwijitalai, Viroj Wiwanitkit
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Generation of Heme Oxygenase-1-Transgenic Rats
Experimental Biology and Medicine, 2003 Heme oxygenase-1 (HO-1) expression protects cells from a variety of cellular insults and inhibits inflammation. However, its role in the regulation of immune responses has not yet been clearly established. We generated HO-1 transgenic rats to directly test the impact of HO-1 on the different immune mechanisms.
C, Braudeau +11 more
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Combined fluorometric analysis of biliverdin and bilirubin by the recombinant protein HUG
MethodsXBiliverdin is a secondary metabolite of heme catabolism. It is formed by the reaction catalyzed by heme oxygenase, which converts the heme group contained in proteins such as hemoglobin, myoglobin, cytochromes, and catalase into biliverdin, iron (II) and
Federica Tramer +5 more
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Heme oxygenase-1 system and gastrointestinal tumors
World Journal of Gastroenterology, 2010 Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors.
Lin, MCM +4 more
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Heme oxygenase-1 and acute kidney injury [PDF]
Current Opinion in Nephrology and Hypertension, 2014 Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide. First shown in acute kidney injury (AKI), HO-1 is now recognized as a protectant against diverse insults in assorted tissues.
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Haematologica, 2010 Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported ...
Samuele Marro +6 more
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