Results 161 to 170 of about 3,016 (188)
Membrane Hemifusion: Crossing a Chasm in Two Leaps [PDF]
Cell, 2005 During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry.
Michael Kozlov, Leonid Chernomordik
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The Pathway to Membrane Fusion through Hemifusion
Current Topics in Membranes, 2011Publisher Summary This chapter discusses the pathway to membrane fusion through hemifusion. Membrane fusion is ubiquitous in life and requires remodeling of two phospholipid bilayers. Many experimental results and theoretical studies support the view that bilayer fusion proceeds through a hemifusion intermediate.
Andreas Herrmann, Ben O'Shaughnessy
exaly +3 more sources
Multi-step formation of a hemifusion diaphragm for vesicle fusion revealed by all-atom molecular dynamics simulations [PDF]
Biochimica Et Biophysica Acta - Biomembranes, 2014 Membrane fusion is essential for intracellular trafficking and virus infection, but the molecular mechanisms underlying the fusion process remain poorly understood.
Hui-Hsu Gavin Tsai
exaly +2 more sources
Trans-SNARE pairing can precede a hemifusion intermediate in intracellular membrane fusion
Nature, 2005 The question concerning whether all membranes fuse according to the same mechanism has yet to be answered satisfactorily. During fusion of model membranes or viruses, membranes dock, the outer membrane leaflets mix (termed hemifusion), and finally the ...
Andreas Mayer
exaly +2 more sources
Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion [PDF]
Cell, 2007 SummaryAutophagy involves de novo formation of double membrane-bound structures called autophagosomes, which engulf material to be degraded in lytic compartments. Atg8 is a ubiquitin-like protein required for this process in Saccharomyces cerevisiae that
Hitoshi Nakatogawa, Yoshinori Ohsumi
exaly +2 more sources
Hemifusion in SNARE-mediated membrane fusion
Nature Structural & Molecular Biology, 2005SNAREs are essential for intracellular membrane fusion. Using EPR, we determined the structure of the transmembrane domain (TMD) of the vesicle (v)-SNARE Snc2p involved in trafficking in yeast. Structural features of the TMD were used to design a v-SNARE mutant in which about half of the TMD was deleted.
Yibin, Xu +4 more
openaire +2 more sources
Visualization of SNARE-Mediated Hemifusion between Giant Unilamellar Vesicles Arrested by Myricetin [PDF]
Frontiers in Molecular Neuroscience, 2017 Neurotransmitters are released within a millisecond after Ca2+ arrives at an active zone. However, the vesicle fusion pathway underlying this synchronous release is yet to be understood. At the center of controversy is whether hemifusion, in which outer leaflets are merged while inner leaflets are still separated, is an on-pathway or off-pathway ...
Dae-Hyuk Kweon +2 more
exaly +4 more sources
Hemifusion of cells using femtosecond laser pulses
SPIE Proceedings, 2015Attachment of single cells via hemifusion of cellular membranes using femtosecond laser pulses is reported in this manuscript. This is a method to attach single cells using sub-10 femtosecond laser pulses, with 800 nm central wavelength delivered from a Ti:Sapphire laser is described.
Nir Katchinskiy +3 more
openaire +1 more source
Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I
Nature Structural & Molecular Biology, 2006Synaptic transmission relies on an exquisitely orchestrated series of protein-protein interactions. Here we show that fusion driven by neuronal SNAREs is inhibited by the regulatory protein complexin. Furthermore, inner-leaflet mixing is strongly impaired relative to total lipid mixing, indicating that inhibition by complexin arrests fusion at ...
Johanna R, Schaub +4 more
openaire +2 more sources
Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion
Biochimica Et Biophysica Acta - Biomembranes, 2021The plasma membrane (PM) is asymmetric in lipid composition. The distinct and characteristic lipid compositions of the exoplasmic and cytoplasmic leaflets lead to different lipid-lipid interactions and physical-chemical properties in each leaflet. The exoplasmic leaflet possesses an intrinsic ability to form coexisting ordered and disordered fluid ...
Frederick Heberle +2 more
exaly +3 more sources