Results 171 to 180 of about 3,016 (188)
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Pathological cardiolipin-promoted membrane hemifusion stiffens pulmonary surfactant membranes
Biophysical Journal, 2022Lower tract respiratory diseases such as pneumonia are pervasive, affecting millions of people every year. The stability of the air/water interface in alveoli and the mechanical performance during the breathing cycle are regulated by the structural and elastic properties of pulmonary surfactant membranes (PSMs). Respiratory dysfunctions and pathologies
Marilyn, Porras-Gómez +4 more
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IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion
Cell Host & Microbe, 2022ABSTRACT Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses through undefined molecular mechanisms. IFITM3 localizes in the endosomal-lysosomal system and specifically impacts virus fusion with target cell membranes. We found that IFITM3 induces local lipid sorting, resulting in
Steffen Klein +18 more
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Short-range specific forces are able to induce hemifusion
European Biophysics Journal, 2001Working with pure lipidic systems (giant unilamellar vesicles, 10-150 microm in diameter) as models for biological membranes, we have considered possible structures of the contact area of two adherent membranes by investigating the diffusion of fluorescent lipid analogues from one vesicle to another.
Pincet, Frédéric +2 more
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Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion
Cell, 1994It has been proposed that membrane fusion events such as virus-cell fusion proceed through a hemifusion intermediate, a state where lipids but not contents of the fusing compartments mix. We engineered the influenza hemagglutinin (HA) such that it would be anchored in membranes via a glycosylphosphatidylinositol (GPI) tail.
G W, Kemble, T, Danieli, J M, White
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Fast Two Dimensional Computer Simulation of Bilayer Hemifusion
Journal of Biomolecular Structure and Dynamics, 1997Computer simulation of model membranes was used to evaluate the possible mechanism of lipid bilayer fusion. The simplified two dimensional model of the membrane cross section was used as an analog of three dimensional reality. Lipid molecules were represented by rod-like structures, and forces between them were limited to attraction/repulsion ...
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Visualization of SNARE-Mediated Organelle Membrane Hemifusion by Electron Microscopy
2018SNARE-mediated membrane fusion is required for membrane trafficking as well as organelle biogenesis and homeostasis. The membrane fusion reaction involves sequential formation of hemifusion intermediates, whereby lipid monolayers partially mix on route to complete bilayer merger.
Sevan, Mattie +4 more
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Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition
Journal of Molecular Biology, 2006SNARE proteins mediate intracellular fusion of eukaryotic membranes. Some SNAREs have previously been shown to dimerise via interaction of their transmembrane domains. However, the functional significance of these interactions had remained unclear. Here, we show that mutating alternate faces of the transmembrane helix of the yeast vacuolar Q-SNARE ...
Mathias W, Hofmann +5 more
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Stalk dynamics and lipid flow upon membrane hemifusion.
Membrane & cell biology, 2000A hydrodynamic theory describing the stalk dynamics and lipid flows upon BLM hemifusion was developed. The value of intermonolayer viscosity, etar, for membranes formed from azolectin mixed with lysophosphatidylcholine (7.10(-4) mg/ml) in n-decane, etar approximately 10(-9) g/s, was determined from comparison of the theoretical calculations and ...
D A, Kumenko +2 more
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