Results 31 to 40 of about 54,391 (157)
Stroke: Vascular and Interventional Neurology, 2023 Introduction It is relatively well recognized that migraine headaches can present with focal neurological deficits. Current guidelines do not exclude such patients from receiving intravenous recombinant tissue plasminogen activator (rt‐PA).
Ahmer Asif +6 more
doaj +1 more source
De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report
The Journal of Headache and Pain, 2017 Background Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the FHM phenotype, thus indicating
Stella Gagliardi +8 more
doaj +1 more source
Lessons from Familial Hemiplegic Migraine and Cortical Spreading Depression [PDF]
, 2017 Migraine is a common episodic neurological disorder with complex pathophysiology. It is generally recognized that: most migraine attacks start in the brain; migraine headache depends on the activation and sensitization of the trigeminovascular pain ...
Daniela Pietrobon, Pietrobon Daniela
core +1 more source
Advances in Migraine Mechanisms and Treatment
Pediatric Neurology Briefs, 2004 Migraine mechanisms are discussed in relation to familial hemiplegic migraine (FHM) genotypes by investigators from the Massachusetts General Hospital, Boston, and Universities in Ankara, Turkey.
J Gordon Millichap
doaj +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland +7 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Christian Staehr +11 more
wiley +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
First FHM3 mouse model shows spontaneous cortical spreading depolarizations
Annals of Clinical and Translational Neurology, 2020 Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse ...
Nico A. Jansen +5 more
doaj +1 more source
The ATP1A2 Mutation Associated with Hemiplegic Migraines: Case Report and Literature Review
Clinical and Translational Neuroscience, 2022 Familial hemiplegic migraine type 2 is a premonitory subtype of migraine caused by an ATP1A2 gene mutation. It is an autosomal dominant genetic disease.
Changyue Liu, Wei Yue
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Epilepsia, Volume 67, Issue 7, Page 3629-3643, July 2026.Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli +43 more
wiley +1 more source