Assessment of the In Vitro and In Vivo Antitumor Activity of Hemocyanins from Helix aspersa, Helix lucorum, and Rapana venosa in a Graffi Myeloid Tumor Model. [PDF]
Biomedicines, 2023 Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of some invertebrate species that attracted scientific interest as potential anticancer agents.
Georgieva A +9 more
europepmc +2 more sources
The evolution of hemocyanin genes in Tectipleura: a multitude of conserved introns in highly diverse gastropods. [PDF]
BMC Ecol Evol, 2021 Background Hemocyanin is the oxygen transporter of most molluscs. Since the oxygen affinity of hemocyanin is strongly temperature-dependent, this essential protein needs to be well-adapted to the environment.
Schäfer GG +4 more
europepmc +4 more sources
CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. [PDF]
PLoS One, 2023 Hemocyanins are multimeric oxygen transport proteins present in the blood of arthropods and molluscs, containing up to 8 oxygen-binding functional units per monomer.
Pasqualetto G +13 more
europepmc +3 more sources
Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells. [PDF]
Front ImmunolIntroductionMollusk hemocyanins are known for their immunomodulatory properties in mammals. Their applications include serving as carrier glycoproteins, functioning as protein-based adjuvants, and acting as non-specific immunostimulants in cancer vaccine
Salazar ML +8 more
europepmc +2 more sources
Hemocyanins: Microscopic Giants with Unique Structural Features for Applications in Biomedicine. [PDF]
Vaccines (Basel)Vaccine adjuvants play a crucial role in the field of vaccinology, yet they remain one of the least developed and poorly characterized components of modern biomedical research.
Salazar ML +6 more
europepmc +2 more sources
Immunotherapeutic Potential of Mollusk Hemocyanins in Murine Model of Melanoma. [PDF]
Mar DrugsThe development of antitumor drugs and therapy requires new approaches and molecules, and products of natural origin provide intriguing alternatives for antitumor research. Gastropodan hemocyanins-multimeric copper-containing glycoproteins have been used
Stoyanova E +7 more
europepmc +2 more sources
De Novo Structural Determination of the Oligosaccharide Structure of Hemocyanins from Molluscs. [PDF]
Biomolecules, 2020 A number of studies have shown that glycosylation of proteins plays diverse functions in the lives of organisms, has crucial biological and physiological roles in pathogen–host interactions, and is involved in a large number of biological events in the ...
Dolashka P +3 more
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Antitumor Properties of Epitope-Specific Engineered Vaccine in Murine Model of Melanoma. [PDF]
Mar Drugs, 2022 Finding new effective compounds of natural origin for composing anti-tumor vaccines is one of the main goals of antitumor research. Promising anti-cancer agents are the gastropodan hemocyanins–multimeric copper-containing glycoproteins used so far for ...
Stoyanova E +8 more
europepmc +2 more sources
Pomacea canaliculata hemocyanin as a novel natural immunostimulant in mammals. [PDF]
Front ImmunolIntroductionGastropod hemocyanins are potent immunostimulants in mammals, a trait associated with their large molecular size and unusual glycosylation patterns.
Chiumiento IR +8 more
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Hemocyanins from Helix and Rapana Snails Exhibit in Vitro Antitumor Effects in Human Colorectal Adenocarcinoma. [PDF]
Biomedicines, 2020 Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and mollusks that attract scientific interest with their diverse biological activities and potential applications in pharmacy and medicine.
Georgieva A +10 more
europepmc +2 more sources