Results 91 to 100 of about 22,483 (254)
American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth +13 more
wiley +1 more source
Haematologica, 2011 Background A deficiency of specific glycosylphosphatidyl inositol-anchored proteins in paroxysmal nocturnal hemoglobinuria may be responsible for most of the clinical features of this disease, but some functional consequences may be indirect. For example,
Anna M. Jankowska +7 more
doaj +1 more source
Equine Veterinary Education, Volume 38, Issue 2, Page e70-e77, February 2026.Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock +7 more
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2013 Descreveram-se os sinais clínicos e achados anatomopatológicos da intoxicação crônica por cobre em um ovino da raça Texxel e definiu-se a conduta diagnóstica correta para confirmação da enfermidade.
M.P. Miguel +4 more
doaj
White Blood Cell Enumeration and Differential by Flow Cytometry: The ICSH WBC Reference Method
International Journal of Laboratory Hematology, Volume 48, Issue 1, Page 93-101, February 2026.ABSTRACT Introduction The current reference method for the white blood cell (WBC) differential is manual smear review as outlined in CLSI H20‐A2. As with many manual methods, it suffers from a number of challenges including dependence upon the expertise of the interpreter, the quality of the smear and stain, when dysplastic features make cell ...
Benjamin D. Hedley +6 more
wiley +1 more source
Clinical Medicine Insights: Blood Disorders, 2013 Discolored urine is a common reason for office visits to a primary care physician and urology referral. Early differentiation of the type or cause of discolored urine is necessary for accurate diagnosis and prompt management.
Prashant Veerreddy MD, MPH
doaj +1 more source
Ravulizumab: a novel C5 inhibitor for the treatment of paroxysmal nocturnal hemoglobinuria
Therapeutic Advances in Hematology, 2019 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare stem cell disorder characterized by hemolytic anemia, bone marrow failure, and thrombosis. Until recently, the complement inhibitor, eculizumab, was the only United States Food and Drug Administration ...
R. Stern, Nathan T Connell
semanticscholar +1 more source
ChemBioChem, Volume 27, Issue 1, January 2026.Protein Z is a vitamin K‐dependent anticoagulant with elusive molecular functions. Herein, it is shown that heme binds to protein Z and induces conformational changes. One histidine‐based heme‐binding motif is identified. High heme‐binding affinity and functional effects are demonstrated on protein level. These findings shed new light on the structural
Paula Lindemann, Marie‐T. Hopp
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.Timeline of events ABSTRACT Moderate‐to‐severe ulcerative colitis can be effectively treated with JAK‐1 inhibition, but platelet counts should be closely monitored, especially in active disease. We confirmed immune‐mediated thrombocytopenia (ITP) in one of our patients after the initiation of filgotinib. Whether this was drug‐induced is uncertain.
M. J. van der Hoff +2 more
wiley +1 more source