Results 71 to 80 of about 6,249 (178)
Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis
HemaSphere, Volume 10, Issue 1, January 2026.Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss +3 more
wiley +1 more source
Matrix Metalloproteinase Inhibition in Melanoma
Experimental Dermatology, Volume 35, Issue 1, January 2026.ABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Ellie Zhang +2 more
wiley +1 more source
Data demonstrating the anti-oxidant role of hemopexin in the heart
Data in Brief, 2017 The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S.
Giada Ingoglia +14 more
doaj +1 more source
HematologyObjective: The limited understanding of venous thromboembolism (VTE) has hindered the development of novel treatment approaches. This study aimed to identify critical factors underlying VTE.Methods: The isobaric tags for relative and absolute ...
Jun-li Zhuang +7 more
doaj +1 more source
Is Hemopexin a Nephrotoxin or a Marker of Kidney Injury in Renal Ischemia-Reperfusion?
BiomoleculesDestabilization of heme proteins is recognized to play a role in acute kidney injury (AKI). Hemopexin (Hpx), known for its role in binding heme, mitigates free heme toxicity. Despite this, the potential adverse effects of Hpx deposition in kidney tissues
You Hyun Jeon +9 more
doaj +1 more source
Cell Reports, 2018 Summary: The clostridium-like ecto-ADP-ribosyltransferase ARTC1 is expressed in a highly restricted manner in skeletal muscle and heart tissue. Although ARTC1 is well studied, the identification of ARTC1 targets in vivo and subsequent characterization of
Mario Leutert +11 more
doaj +1 more source
Targeting heme in sickle cell disease: new perspectives on priapism treatment
Frontiers in PhysiologyMen with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated
Tammyris Helena Rebecchi Silveira +4 more
doaj +1 more source
Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury
Frontiers in ImmunologyIntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation.
Tomoyuki Nakagiri +14 more
doaj +1 more source
Zinc Chelates Bind Human Hemopexin. [PDF]
Acta Chemica Scandinavica, 1991 Poul Erik Hyldgaard Jensen +5 more
openaire +2 more sources