Results 51 to 60 of about 4,142 (152)

Integrating host condition into spatiotemporal multiscale models improves virus shedding predictions

Ecography, Volume 2025, Issue 9, September 2025.
Understanding where and when pathogens occur in the environment has implications for reservoir population health and infection risk. In reservoir hosts, infection status and pathogen shedding are affected by processes interacting across different scales: from landscape features affecting host location and transmission to within‐host processes affecting
Andrew M. Kramer, Christina L. Faust, Adrian A. Castellanos, Ilya R. Fischhoff, Alison J. Peel, Peggy Eby, Manuel Ruiz‐Aravena, Benny Borremans, Raina K. Plowright, Barbara A. Han   +9 more
wiley   +1 more source

High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia

Emerging Infectious Diseases, 2020
We conducted an in-depth characterization of the Nipah virus (NiV) isolate previously obtained from a Pteropus lylei bat in Cambodia in 2003 (CSUR381). We performed full-genome sequencing and phylogenetic analyses and confirmed CSUR381 is part of the NiV-
Maria Gaudino, Noémie Aurine, Claire Dumont, Julien Fouret, Marion Ferren, Cyrille Mathieu, Olivier Reynard, Viktor E. Volchkov, Catherine Legras-Lachuer, Marie-Claude Georges-Courbot, Branka Horvat   +10 more
doaj   +1 more source

Henipavirus infection of the central nervous system [PDF]

Pathogens and Disease, 2019
ABSTRACTNipah virus (NiV) and Hendra virus are highly pathogenic zoonotic viruses of the genus Henipavirus, family Paramyxoviridae. These viruses were first identified as the causative agents of severe respiratory and encephalitic disease in the 1990s across Australia and Southern Asia with mortality rates reaching up to 75%.
Brian E, Dawes, Alexander N, Freiberg
openaire   +2 more sources

Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot

Global Change Biology, Volume 31, Issue 9, September 2025.
Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz, Ada Chornelia, Alice C. Hughes   +2 more
wiley   +1 more source

Differential Features of Fusion Activation within the Paramyxoviridae

Viruses, 2020
Paramyxovirus (PMV) entry requires the coordinated action of two envelope glycoproteins, the receptor binding protein (RBP) and fusion protein (F). The sequence of events that occurs during the PMV entry process is tightly regulated.
Kristopher D. Azarm, Benhur Lee
doaj   +1 more source

Henipavirus: A Review of Laboratory Animal Pathology [PDF]

Veterinary Pathology, 2010
The genus Henipavirus contains two members—Hendra virus (HeV) and Nipah virus (NiV)—and each can cause fatal disease in humans and animals. HeV and Niv are currently classified as biosafety level 4, and NiV is classified as a category C priority pathogen.
M M, Williamson, F J, Torres-Velez
openaire   +2 more sources

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, Volume 12, Issue 27, July 17, 2025.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect

Cells, 2021
Nipah virus (NiV) is a highly pathogenic zoonotic virus with a broad species tropism, originating in pteropid bats. Human outbreaks of NiV disease occur almost annually, often with high case-fatality rates.
Blair L. DeBuysscher, Dana P. Scott, Rebecca Rosenke, Victoria Wahl, Heinz Feldmann, Joseph Prescott   +5 more
doaj   +1 more source

From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley   +1 more source

Modes of paramyxovirus fusion: a Henipavirus perspective [PDF]

Trends in Microbiology, 2011
Henipavirus is a new genus of Paramyxoviridae that uses protein-based receptors (ephrinB2 and ephrinB3) for virus entry. Paramyxovirus entry requires the coordinated action of the fusion (F) and attachment viral envelope glycoproteins. Receptor binding to the attachment protein triggers F to undergo a conformational cascade that results in membrane ...
Benhur, Lee, Zeynep Akyol, Ataman
openaire   +2 more sources