Results 1 to 10 of about 44,107 (222)

European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe

Journal of Veterinary Internal Medicine, 2022
Horses and other equids can be infected with several viruses of the family Flaviviridae, belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on viruses with known occurrence in Europe, with the objective to summarize the ...
Jessika‐M. V. Cavalleri, Orsolya Korbacska‐Kutasi, Agnès Leblond, Romain Paillot, Nicola Pusterla, Eike Steinmann, Joy Tomlinson   +6 more
doaj   +1 more source

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Journal of Virology, 2023
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat.
Raphael Wolfisberg, Kenn Holmbeck, E. Billerbeck, Caroline E. Thorselius, M. N. Batista, U. Fahnøe, Emma A. Lundsgaard, M. J. Kennedy, Louise Nielsen, C. Rice, J. Bukh, T. Scheel   +11 more
semanticscholar   +1 more source

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +1 more source

Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy

Transboundary and Emerging Diseases, 2023
Equine hepacivirus (EqHV), also known as Hepacivirus A, represents the most closely related genetic homologue of human hepatitis C virus (HCV). Although detected worldwide, limited information on the clinical features of this infection is available and ...
Robert A. Cardone, A. Buonavoglia, G. Lanave, V. Vasinioti, Valentina Mininni, E. Lorusso, N. Decaro, V. Martella, G. Elia, G. Diakoudi   +9 more
semanticscholar   +1 more source

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV

Hepatology, 2022
Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining characteristics, including liver ...
Raphael Wolfisberg, Caroline E. Thorselius, E. Salinas, Elizabeth J. Elrod, Sheetal Trivedi, Louise Nielsen, U. Fahnøe, A. Kapoor, A. Grakoui, C. Rice, J. Bukh, Kenn Holmbeck, T. Scheel   +12 more
semanticscholar   +1 more source

The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus)proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist.

Voprosy virusologii, 2023
INTRODUCTION Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
E. Lesnova, O. Masalova, K. Y. Permyakova, Natalia A. Demidova, V. Valuev-Elliston, Alexander V. Ivanov, Alla A. Kushch   +6 more
semanticscholar   +1 more source

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +1 more source

Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication [PDF]

, 2014
Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown.
Boros, Ákos, Maza, Norbert, Pankovics, Péter, Reuter, Gábor   +3 more
core   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources