Results 1 to 10 of about 15,836 (133)

Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China. [PDF]

Front Vet Sci
The genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Chen JT, Chen KJ, Wu KW, Yi SH, Shao JW.
europepmc   +4 more sources

First National Prevalence in Italian Horse Population and Phylogenesis Highlight a Fourth Sub-Type Candidate of Equine Hepacivirus. [PDF]

Viruses
equine hepacivirus (EqHV, Flaviviridae, hepacivirus) is a small, enveloped RNA virus generally causing sub-clinical hepatitis with occasional fatalities. EqHV is reported in equids worldwide, but for Italy data are limited.
Nardini R, Pacchiarotti G, Svicher V, Salpini R, Bellocchi MC, Conti R, Sala MG, La Rocca D, Carioti L, Cersini A, Manna G, The Equine Hepatic Viruses Consortium, Scicluna MT.   +12 more
europepmc   +4 more sources

Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China. [PDF]

Pathogens, 2023
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Guo L, Li B, Han P, Dong N, Zhu Y, Li F, Si H, Shi Z, Wang B, Yang X, Zhang Y.   +10 more
europepmc   +2 more sources

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]

PLoS Pathog
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Lopez-Scarim J, Mendoza D, Nambiar SM, Billerbeck E.   +3 more
europepmc   +2 more sources

Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia. [PDF]

Viruses
Reports of newly discovered equine hepatotropic flavi- and parvoviruses have emerged throughout the last decade in many countries, the discovery of which has stimulated a great deal of interest and clinical research.
Fortier C, El-Hage C, Normand C, Hue ES, Sutton G, Marcillaud-Pitel C, Jeffers K, Bamford N, Oden E, Paillot R, Hartley C, Gilkerson J, Pronost S.   +12 more
europepmc   +2 more sources

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice. [PDF]

Hepatology, 2023
Background & Aims Human genetic variation is thought to guide the outcome of hepatitis C virus (HCV) infection but model systems within which to dissect these host genetic mechanisms are limited.
Brown AJ, Won JJ, Wolfisberg R, Fahnøe U, Catanzaro N, West A, Moreira FR, Nogueira Batista M, Ferris MT, Linnertz CL, Leist SR, Nguyen C, De la Cruz G, Midkiff BR, Xia Y, Evangelista MD, Montgomery SA, Billerbeck E, Bukh J, Scheel TKH, Rice CM, Sheahan TP.   +21 more
europepmc   +2 more sources

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Badenhorst, Marcha, Baumgärtner, Wolfgang, Brandner, Sabine, Cavalleri, Jessika-M V, Daly, Janet M, de le Roi, Madeleine, Delarocque, Julien, Engelmann, Michael, Ertl, Reinhard, Heelemann, Steffen, Junge, Hannah K, Krey, Thomas, Pratscher, Barbara, Puff, Christina, Saalmüller, Armin, Saunier, Bertrand, Stadler, Maria, Steinmann, Eike, Todt, Daniel, Volz, Asisa, Wagner, Bettina, Wittmann, Johannes   +21 more
core   +2 more sources

Phenotype and Fate of Liver-Resident CD8 T Cells During Acute and Chronic Hepacivirus Infection [PDF]

PLoS Pathogens, 2023
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice.
Attia, Zayed, Cassady, Cole, Chandra, Rahul, Cullen, John M, Dravid, Piyush, Grakoui, Arash, Gridley, John, Holland, Brantley, Kapoor, Amit, Kumari, Anuradha, Murthy, Satyapramod, Sharma, Himanshu, Trivedi, Sheetal, Vyas, Ashish, Walker, Christopher M   +14 more
core   +3 more sources

Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China. [PDF]

Front Cell Infect Microbiol
Background Bovine hepacivirus (BovHepV) is a recently identified member of the expanding genus Hepacivirus within the family Flaviviridae. However, the genetic diversity, geographical distribution, and host range of the virus remains poorly understood ...
Ma J, Wei Z, Li L, Wang W, Liu Z, Liu N, Wei F, Zheng X, Wang Z.   +8 more
europepmc   +2 more sources

Two bovine hepacivirus genome sequences from U.S. cattle. [PDF]

J Vet Diagn Invest
Bovine hepacivirus (BoHV) is closely related to the hepatitis C virus (HCV) in humans and can cause both acute and chronic liver infections in cattle.
Workman AM, Harhay GP, Groves JT, Vander Ley BL.   +3 more
europepmc   +2 more sources