Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China [PDF]
The genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Jin-Tao Chen+4 more
doaj +9 more sources
An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst+21 more
doaj +8 more sources
Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China [PDF]
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo+10 more
doaj +5 more sources
CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim+3 more
doaj +4 more sources
Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy [PDF]
Equine hepacivirus (EqHV), also known as Hepacivirus A, represents the most closely related genetic homologue of human hepatitis C virus (HCV). Although detected worldwide, limited information on the clinical features of this infection is available and ...
Roberta Cardone+9 more
semanticscholar +4 more sources
First National Prevalence in Italian Horse Population and Phylogenesis Highlight a Fourth Sub-Type Candidate of Equine Hepacivirus. [PDF]
equine hepacivirus (EqHV, Flaviviridae, hepacivirus) is a small, enveloped RNA virus generally causing sub-clinical hepatitis with occasional fatalities. EqHV is reported in equids worldwide, but for Italy data are limited.
Nardini R+12 more
europepmc +6 more sources
The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection [PDF]
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs+14 more
doaj +10 more sources
Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection [PDF]
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus+3 more
doaj +3 more sources
Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China [PDF]
Bovine hepacivirus (BovHepV) is a member of the genus Hepacivirus of the family Flaviviridae, which can cause acute or persistent infections in cattle.
Sheng Yuan+5 more
doaj +3 more sources
Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China. [PDF]
Background Bovine hepacivirus (BovHepV) is a recently identified member of the expanding genus Hepacivirus within the family Flaviviridae. However, the genetic diversity, geographical distribution, and host range of the virus remains poorly understood ...
Ma J+8 more
europepmc +4 more sources