Results 1 to 10 of about 13,869 (203)

Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy. [PDF]

Transbound Emerg Dis, 2023
Equine hepacivirus (EqHV), also known as Hepacivirus A, represents the most closely related genetic homologue of human hepatitis C virus (HCV). Although detected worldwide, limited information on the clinical features of this infection is available and on the mechanisms by which EqHV is transmitted.
Cardone R, Buonavoglia A, Lanave G, Vasinioti VI, Mininni V, Lorusso E, Decaro N, Martella V, Elia G, Diakoudi G.   +9 more
europepmc   +6 more sources

Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China [PDF]

Frontiers in Veterinary Science
The genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Jin-Tao Chen, Kang-Jing Chen, Kang-Wei Wu, Shan-Hong Yi, Jian-Wei Shao   +4 more
doaj   +6 more sources

Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China [PDF]

Pathogens, 2023
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo, Bei Li, Peiyu Han, Na Dong, Yan Zhu, Fuli Li, Haorui Si, Zhengli Shi, Bo Wang, Xinglou Yang, Yunzhi Zhang   +10 more
doaj   +5 more sources

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +4 more sources

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
doaj   +6 more sources

Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection [PDF]

Frontiers in Immunology, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus, Jarrett Lopez-Scarim, Joshua Luthy, Eva Billerbeck   +3 more
doaj   +3 more sources

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
doaj   +4 more sources

Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China [PDF]

Frontiers in Veterinary Science, 2023
Bovine hepacivirus (BovHepV) is a member of the genus Hepacivirus of the family Flaviviridae, which can cause acute or persistent infections in cattle.
Sheng Yuan, Xin-Yan Yao, Chun-Yang Lian, Sa Kong, Jian-Wei Shao, Xue-Lian Zhang   +5 more
doaj   +3 more sources

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Journal of Virology, 2023
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Raphael Wolfisberg, Kenn Holmbeck, Eva Billerbeck, Caroline E. Thorselius, Mariana N. Batista, Ulrik Fahnøe, Emma A. Lundsgaard, Matthew J. Kennedy, Louise Nielsen, Charles M. Rice, Jens Bukh, Troels K. H. Scheel   +11 more
semanticscholar   +6 more sources

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +3 more sources