Results 1 to 10 of about 15,872 (238)

Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China [PDF]

Frontiers in Veterinary Science
The genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Jin-Tao Chen, Kang-Jing Chen, Kang-Wei Wu, Shan-Hong Yi, Jian-Wei Shao   +4 more
doaj   +7 more sources

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
doaj   +8 more sources

Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China [PDF]

Pathogens, 2023
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo, Bei Li, Peiyu Han, Na Dong, Yan Zhu, Fuli Li, Haorui Si, Zhengli Shi, Bo Wang, Xinglou Yang, Yunzhi Zhang   +10 more
doaj   +5 more sources

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +4 more sources

First National Prevalence in Italian Horse Population and Phylogenesis Highlight a Fourth Sub-Type Candidate of Equine Hepacivirus. [PDF]

Viruses
equine hepacivirus (EqHV, Flaviviridae, hepacivirus) is a small, enveloped RNA virus generally causing sub-clinical hepatitis with occasional fatalities. EqHV is reported in equids worldwide, but for Italy data are limited.
Nardini R, Pacchiarotti G, Svicher V, Salpini R, Bellocchi MC, Conti R, Sala MG, La Rocca D, Carioti L, Cersini A, Manna G, The Equine Hepatic Viruses Consortium, Scicluna MT.   +12 more
europepmc   +6 more sources

Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China [PDF]

Frontiers in Veterinary Science, 2023
Bovine hepacivirus (BovHepV) is a member of the genus Hepacivirus of the family Flaviviridae, which can cause acute or persistent infections in cattle.
Sheng Yuan, Xin-Yan Yao, Chun-Yang Lian, Sa Kong, Jian-Wei Shao, Xue-Lian Zhang   +5 more
doaj   +5 more sources

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection [PDF]

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +9 more sources

Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection [PDF]

Frontiers in Immunology, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus, Jarrett Lopez-Scarim, Joshua Luthy, Eva Billerbeck   +3 more
doaj   +3 more sources

Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia. [PDF]

Viruses
Reports of newly discovered equine hepatotropic flavi- and parvoviruses have emerged throughout the last decade in many countries, the discovery of which has stimulated a great deal of interest and clinical research.
Fortier C, El-Hage C, Normand C, Hue ES, Sutton G, Marcillaud-Pitel C, Jeffers K, Bamford N, Oden E, Paillot R, Hartley C, Gilkerson J, Pronost S.   +12 more
europepmc   +4 more sources

Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection. [PDF]

PLoS Pathog, 2023
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice.
Dravid P, Murthy S, Attia Z, Cassady C, Chandra R, Trivedi S, Vyas A, Gridley J, Holland B, Kumari A, Grakoui A, Cullen JM, Walker CM, Sharma H, Kapoor A.   +14 more
europepmc   +4 more sources