Results 1 to 10 of about 43,413 (249)

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection [PDF]

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +5 more sources

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

bioRxiv, 2023
Background & Aims Human genetic variation is thought to guide the outcome of hepatitis C virus (HCV) infection but model systems within which to dissect these host genetic mechanisms are limited.
Ariane J. Brown, John J. Won, Raphael Wolfisberg, U. Fahnøe, Nicholas J. Catanzaro, A. West, Fernando R. Moreira, M. N. Batista, M. Ferris, Colton L. Linnertz, S. Leist, Cameron Nguyen, G. de la Cruz, B. Midkiff, Yongjuan Xia, S. Montgomery, E. Billerbeck, J. Bukh, T. Scheel, C. Rice, T. Sheahan   +20 more
semanticscholar   +1 more source

Identification of a novel hepacivirus in Mongolian gerbil (Meriones unguiculatus) from Shaanxi, China

Virologica Sinica, 2022
Cuihong An, Juan Li, Yi‐Ting Wang, Shou-min Nie, Wenhui Chang, Hong Zhou, Lin Xu, Yang-xin Sun, Weifeng Shi, Cixiu Li   +9 more
openalex   +2 more sources

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +1 more source

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection

PLoS Pathogens, 2023
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice.
Piyush Dravid, S. Murthy, Zayed Attia, Cole Cassady, Rahul Chandra, Sheetal Trivedi, Ashish Vyas, John Gridly, Brantley Holland, Anuradha Kumari, A. Grakoui, John M Cullen, Christopher M Walker, Himanshu Sharma, Amit Kapoor   +14 more
semanticscholar   +1 more source

The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus)proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist.

Voprosy virusologii, 2023
INTRODUCTION Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
E. Lesnova, O. Masalova, K. Y. Permyakova, Natalia A. Demidova, V. Valuev-Elliston, Alexander V. Ivanov, Alla A. Kushch   +6 more
semanticscholar   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication [PDF]

, 2014
Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown.
Boros, Ákos, Maza, Norbert, Pankovics, Péter, Reuter, Gábor   +3 more
core   +1 more source

Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV

Hepatology, 2022
Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining characteristics, including liver ...
Raphael Wolfisberg, Caroline E. Thorselius, E. Salinas, Elizabeth J. Elrod, Sheetal Trivedi, Louise Nielsen, U. Fahnøe, A. Kapoor, A. Grakoui, C. Rice, J. Bukh, K. Holmbeck, T. Scheel   +12 more
semanticscholar   +1 more source