Results 51 to 60 of about 16,038 (235)

Acute and chronic infections with nonprimate hepacivirus in young horses [PDF]

Veterinary Research, 2016
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months.
Gather, Theresa, Walter, Stephanie, Pfaender, Stephanie, Todt, Daniel, Feige, Karsten, Steinmann, Eike, Cavalleri, Jessika M. V.   +6 more
openaire   +5 more sources

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Shoujun Li, Ji Huang, Gang Lu, Xiaokun Ping, Peixin Wu, Aijian Luo, Kun Jia   +6 more
openaire   +3 more sources

Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals [PDF]

Viruses, 2019
(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer.
Stephane Pronost, Christine Fortier, Christel Marcillaud-Pitel, Jackie Tapprest, Marc Foursin, Bertrand Saunier, Pierre-Hugues Pitel, Romain Paillot, Erika S. Hue   +8 more
openaire   +6 more sources

Design principles and applications of synthetic self‐replicating RNAs

WIREs RNA, Volume 14, Issue 6, November/December 2023., 2023
Self‐replicating RNAs (srRNAs) replicate enzymatically in the cytosol. Depending on their bespoke gene cargo, srRNAs can be transformed into powerful tools for various applications. Abstract With the advent of ever more sophisticated methods for the in vitro synthesis and the in vivo delivery of RNAs, synthetic mRNAs have gained substantial interest ...
Alexander Wagner, Hannes Mutschler
wiley   +1 more source

Hepatic immunopathology during occult hepacivirus re-infection [PDF]

Virology, 2017
Despite drug advances for Hepatitis C virus (HCV), re-infections remain prevalent in high-risk populations. Unfortunately, the role of preexisting viral immunity and how it modulates re-infection is unclear. GBV-B infection of common marmosets is a useful model to study tissue immune responses in hepacivirus infections, and in this study we re ...
Cordelia Manickam, Amanda J. Martinot, Rhianna Jones, Valerie Varner, R. Keith Reeves   +4 more
openalex   +4 more sources

The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus

Molecular Ecology, Volume 32, Issue 15, Page 4242-4258, August 2023., 2023
Abstract Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses.
Louise Cheynel, Luke Lazarou, Eleanor M. Riley, Mark Viney   +3 more
wiley   +1 more source

Hepatitis C subtyping assay failure in UK patients born in sub‐Saharan Africa: Implications for global treatment and elimination

Journal of Medical Virology, Volume 95, Issue 1, January 2023., 2023
Abstract Background and Aims The newly developed direct‐acting antivirals have revolutionized the treatment of chronic hepatitis C virus (HCV), with cure rates as high as 98% in some cohorts. Although genome sequencing has demonstrated that some subtypes of HCV naturally harbor drug resistance associated substitutions (RAS), these are often overlooked ...
Kazeem Adeboyejo, Barnabas J. King, Theocharis Tsoleridis, Alexander W. Tarr, John McLauchlan, William L. Irving, Jonathan K. Ball, C. Patrick McClure   +7 more
wiley   +1 more source

Presence of a Novel Subtype of Bovine Hepacivirus in China and Expanded Classification of Bovine Hepacivirus Strains Worldwide into 7 Subtypes [PDF]

Viruses, 2019
The newest member of the Hepacivirus genus, bovine hepacivirus (BovHepV), was first identified in cattle in 2015 and is a novel hepacivirus C virus (HCV)-like virus. This virus has been detected in five countries so far and is classified into four subtypes.
Lu, Gang, Ou, Jiajun, Zhao, Jiawei, Li, Shoujun   +3 more
openaire   +3 more sources

Blocking Zika virus vertical transmission. [PDF]

, 2018
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB, Corbett, Kevin D, Cugola, Fernanda R, Fernandes, Isabella R, Herai, Roberto H, Huang, Chun-Teng, Kolar, Matthew J, Macia, Angela, Mesci, Pinar, Momper, Jeremiah D, Montefusco, Sandro, Moore, Spencer M, Muotri, Alysson R, Pinto, Antonella, Rosenberg, Scott C, Russo, Fabiele B, Saghatelian, Alan, Sheets, Nicholas, Shiryaev, Sergey A, Shresta, Sujan, Siqueira-Neto, Jair L, Suarez, Nicole A, Tejwani, Leon, Terskikh, Alexey V   +23 more
core   +2 more sources