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Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling
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Heparan Sulfate Proteoglycans in Diabetes [PDF]
Seminars in Thrombosis and Hemostasis, 2021 AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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The heparitin sulfates (heparan sulfates)
Carbohydrate Research, 1973Heparitin sulfate has been isolated from several sources, namely: a commercial lung polysaccharide preparation, beef lung, beef aorta, human amyloid liver, human intestine, and urine of a patient with mucopolysaccharidosis. The polysaccharides isolated were extensively purified, fractionated, and characterized.
Peter Hovingh, Alfred Linker
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Functions of cell surface heparan sulfate proteoglycans.
Annual Review of Biochemistry, 1999The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide ...
M. Bernfield +6 more
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The heparan sulfate of rat brain
Biochimica et Biophysica Acta (BBA) - General Subjects, 1972Heparan sulfate comprises 14% of the total mucopolysaccharide content of rat brain. Two heparan sulfate fractions (HS-I and HS-II) can be obtained by gradient elution from Dowex I (chloride). HS-I is eluted with i.o. M NaCl and accounts for approximately one third of the total heparan sulfate, while HS-II, accounting for the remaining two thirds of the
Richard U. Margolis, Donna M. Atherton
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2010
Vascular endothelial cells (ECs) produce anticoagulant heparan sulfate (HSAT+)-a small subpopulation of heparan sulfate (HS) containing a specific pentasaccharide motif with high affinity for plasma antithrombin (AT). This pentasaccharide is responsible for the anticoagulant action of therapeutic heparin, which dramatically catalyzes AT neutralization ...
Ariane De Agostini +3 more
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Vascular endothelial cells (ECs) produce anticoagulant heparan sulfate (HSAT+)-a small subpopulation of heparan sulfate (HS) containing a specific pentasaccharide motif with high affinity for plasma antithrombin (AT). This pentasaccharide is responsible for the anticoagulant action of therapeutic heparin, which dramatically catalyzes AT neutralization ...
Ariane De Agostini +3 more
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Heparan sulfate: a piece of information
The FASEB Journal, 1996The sulfated glycosaminoglycans, heparan sulfate and heparin, are increasingly implicated in cell-biological processes such as cytokine action, cell adhesion, and regulation of enzymic catalysis. These activities generally depend on interactions of the polysaccharides with proteins, mediated by distinct saccharide sequences, and expressed at various ...
Ulf Lindahl +2 more
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Antithrombin, heparin, and heparan sulfate
Critical Care Medicine, 2002To review the experimental and clinical evidence that antithrombin has multiple mechanisms for both its anticoagulant and anti-inflammatory properties. The interaction between antithrombin and specific polysulfated, acidic oligosaccharide moieties found on heparin and related proteoglycan molecules within the circulation and on endothelial surfaces ...
Juergen Roemisch +3 more
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Heparan sulfate and inflammation
Nature Immunology, 2005Entry of leukocytes into tissues is a key feature of inflammation. New data suggest the polysaccharide heparan sulfate is required for several stages of this entry process.
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