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Tinkering with heparan sulfate sulfation to steer development
Trends in Cell Biology, 2007Heparan sulfate (HS) proteoglycans, at the cell surface and extracellular matrix, facilitate ligand-receptor interactions crucial to many physiological processes. The distinct sulfation patterns of HS sugar chains presented by their protein core are key to HS proteoglycan activity. Tight regulation of several Golgi complex enzyme families is crucial to
Gorsi, Bushra, Stringer, Sally E.
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Heparan Sulfate in the Tumor Microenvironment
2020The biology of tumor cells strictly depends on their microenvironment architecture and composition, which controls the availability of growth factors and signaling molecules. Thus, the network of glycosaminoglycans, proteoglycans, and proteins known as extracellular matrix (ECM) that surrounds the cells plays a central role in the regulation of tumor ...
Davide Vigetti +8 more
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Biological Activities of Heparan Sulfate
2014Heparan sulfate was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantified in crude as well as purified samples and they were estimated as 2.72 and 2.2g/kg (crude) and 260 and 248 mg/g (purified) in T. maxima and P. viridis, respectively.
Muthuvel Arumugam, Sadhasivam Giji
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The anticoagulant effect of heparan sulfate and dermatan sulfate
Thrombosis Research, 1976Abstract The potency of the various glycosaminoglycans (GAGs) as anticoagulants in the activated partial thromboplastin time (APTT) test system has been investigated. Heparin, heparan sulfate (HS) and dermatan sulfate (DS) exhibit anticoagulant effect.
Magnus Höök +2 more
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao Zhang, Jin-Ping Li
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Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Annual Review of Biochemistry, 2002Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal ...
J. Esko, S. Selleck
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Structure of Heparan Sulfate and Dermatan Sulfate
Annals of the New York Academy of Sciences, 1989openaire +3 more sources
The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate
Glycoconjugate Journal, 2016Rana El Masri +3 more
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Autoantibodies to heparan sulfate proteoglycans
Autoimmunity Reviews, 2002Maryvonne Dueymes +4 more
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