Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function [PDF]
Matrix Biology Plus, 2022 The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius +4 more
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Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth [PDF]
eLife, 2022 The Ewing sarcoma family of tumors is a group of malignant small round blue cell tumors (SRBCTs) that affect children, adolescents, and young adults.
Elena Vasileva +3 more
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Heparan Sulfate Proteoglycans in Tauopathy
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
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Heparan Sulfate Proteoglycan Clustering in Wnt Signaling and Dispersal [PDF]
Frontiers in Cell and Developmental Biology, 2020 Wnt, a family of secreted signal proteins, serves diverse functions in animal development, stem cell systems, and carcinogenesis. Although Wnt is generally considered a morphogen, the mechanism by which Wnt ligands disperse is still debated.
Yusuke Mii +6 more
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Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment. [PDF]
Int J Mol Sci, 2020 In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale V, Pavone LM.
europepmc +5 more sources
Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection [PDF]
Frontiers in MedicineThe global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang +3 more
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Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity [PDF]
Frontiers in Oncology, 2019 Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes.
Jlenia Brunetti +9 more
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Heparan Sulfate Proteoglycans in Human Colorectal Cancer
Analytical Cellular Pathology, 2018 Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
Carolina Meloni Vicente +7 more
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Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells [PDF]
International Journal of Nanomedicine, 2018 Wei Xiong Siow,1,2 Yi-Ting Chang,1,2 Michal Babič,3 Yi-Ching Lu,2 Daniel Horák,3 Yunn-Hwa Ma1,2,4 1Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan, Republic of China; 2Department of ...
Siow WX +5 more
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Cell Density-Dependent Suppression of Perlecan and Biglycan Expression by Gold Nanocluster in Vascular Endothelial Cells [PDF]
CellsProteoglycans are macromolecules consisting of a core protein and one or more glycosaminoglycan side chains. Proteoglycans synthesized by vascular endothelial cells modulate various functions such as anticoagulant activity and vascular permeability.
Takato Hara +5 more
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