Results 21 to 30 of about 250,900 (178)

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

npj Regenerative Medicine, 2022
Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein.
Charlie Colin-Pierre, Oussama El Baraka, Louis Danoux, Vincent Bardey, Valérie André, Laurent Ramont, Stéphane Brézillon   +6 more
doaj   +1 more source

Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models

Life Science Alliance, 2022
This study offers new Caenorhabditis elegans models in which feeding with α-synuclein pre-formed fibrils results in prion-like aggregation of host α-synuclein and dopamine neuron degeneration, and these disease phenotypes are regulated by the heparan ...
Merry Chen, Julie Vincent, Alexis Ezeanii, Saurabh Wakade, Shobha Yerigenahally, Danielle E Mor   +5 more
doaj   +1 more source

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. [PDF]

, 1995
Agrin is an extracellular matrix (ECM) protein with a calculated relative molecular mass of more than 200 kD that induces the aggregation of acetylcholine receptors (AChRs) at the neuromuscular junction. This activity has been mapped to its COOH terminus.
Ruegg, M. A., A J Denzer, B Schumacher, Denzer, A J, M A Ruegg, Gesemann, M., Schumacher, B, M Gesemann, Schumacher, B., Gesemann, M, Ruegg, M A, Denzer, A. J., Denzer AJ, Gesemann M, Schumacher B, Ruegg MA   +15 more
core   +1 more source

The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Frontiers in Immunology, 2017
Thoracoabdominal aortic aneurysm (TAAA) is a highly lethal disorder requiring open or endovascular TAAA repair, both of which are rare, but extensive and complex surgical procedures associated with a significant systemic inflammatory response and high ...
Lukas Martin, Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz, Tobias Schuerholz   +11 more
doaj   +1 more source

Agrin binds to the nerve-muscle basal lamina via laminin. [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Brandenberger, R, Ralph Brandenberger, Matthias Gesemann, Gesemann, M., Denzer, A. J., Chiquet, M, Ruegg, M. A., Denzer, A J, Brandenberger, R., Markus A. Ruegg, Matthias Chiquet, Gesemann, M, Ruegg, M A, Chiquet, M., Alain J. Denzer, Chiquet M, Denzer AJ, Gesemann M, Brandenberger R, Ruegg MA   +19 more
core   +1 more source

Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

ASN Neuro, 2010
The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-ζ/β and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by ...
Mary Abaskharoun, Marie Bellemare, Elizabeth Lau, Richard U Margolis   +3 more
doaj   +1 more source

Effect of epithelial debridement on human cornea proteoglycans

Brazilian Journal of Medical and Biological Research, 2001
Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano, M.S.Q. Campos, J.A.K. Aguiar, Y.M. Michelacci   +3 more
doaj   +1 more source

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X [PDF]

, 2010
Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown.
Angela C Bradshaw, Duffy, Margaret R., Andrew H. Baker, Lynda Coughlan, Coughlan Lynda, Baker Andrew H., van Rooijen, Nico, van Rooijen, N., Nicklin, Stuart A., Margaret R Duffy, Parker, A.L., Kahari, V.M., Alan L Parker, Kähäri Veli-Matti, Stuart A Nicklin, Nico van Rooijen, Andrew H Baker, Coughlan, L., Nicklin Stuart A., Coughlan, Lynda, Kahari, Veli-Matti, Duffy, M.R., Parker Alan L., Bradshaw Angela C., Parker, Alan L., Duffy Margaret R., Bradshaw, Angela C., Bradshaw, A.C., Veli-Matti Kähäri, Angela C. Bradshaw, Alan L. Parker, Margaret R. Duffy, Stuart A. Nicklin, Baker, Andrew H., Baker, A.H., Nicklin, S.A., van Rooijen Nico   +36 more
core   +2 more sources

Viral pathogens hitchhike with insect sperm for paternal transmission

Nature Communications, 2019
Arbovirus vertical transmission is commonly mediated by transovarial passage of female insect vectors. Here, the authors show that Rice gall dwarf virus can be transmitted by male leafhoppers via interactions of the viral capsid and heparan sulfate ...
Qianzhuo Mao, Wei Wu, Zhenfeng Liao, Jiajia Li, Dongsheng Jia, Xiaofeng Zhang, Qian Chen, Hongyan Chen, Jing Wei, Taiyun Wei   +9 more
doaj   +1 more source

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +2 more sources