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Heparan Sulfate Proteoglycans in Diabetes [PDF]

open access: possibleSeminars in Thrombosis and Hemostasis, 2021
AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Development of Molecules Antagonizing Heparan Sulfate Proteoglycans [PDF]

open access: possibleSeminars in Thrombosis and Hemostasis, 2021
AbstractHeparan sulfate proteoglycans (HSPGs) occur in almost every tissue of the human body and consist of a protein core, with covalently attached glycosaminoglycan polysaccharide chains. These glycosaminoglycans are characterized by their polyanionic nature, due to sulfate and carboxyl groups, which are distributed along the chain.
Tiziana Adage   +4 more
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