Results 31 to 40 of about 20,897 (221)
Cardiovascular Diabetology, 2004 Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N +4 more
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Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis
Frontiers in Genetics, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
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The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis [PDF]
Matrix Biology, 2018 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in lipid homeostasis and inflammation. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions in the context of cardiovascular disease ...
Philip L.S.M. Gordts, Jeffrey D. Esko
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Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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Immunopurification and characterization of a neuronal heparan sulfate proteoglycan [PDF]
The Journal of Neuroscience, 1985 We have identified a unique heparan sulfate (HeS) proteoglycan synthesized by the neuronal-like cell line PC12. The proteoglycan, purified with monoclonal antibodies from medium conditioned by PC12 cells, has an apparent molecular weight of 350,000, and it contains a Mr 80,000 core protein and HeS side chains of Mr 15,000 each.
Matthew, WD +3 more
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth
Neoplasia: An International Journal for Oncology Research, 2016 In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal +7 more
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Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
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Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
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Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]
Journal of Biological Chemistry, 2008 Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Vy M. Tran +4 more
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Heparan sulfate proteoglycans: structure, protein interactions and cell signaling
Anais da Academia Brasileira de Ciências, 2009 Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions ...
Juliana L. Dreyfuss +5 more
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