Results 31 to 40 of about 17,555 (155)

Chemical Tumor Biology of Heparan Sulfate Proteoglycans [PDF]

Current Chemical Biology, 2010
Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant ...
Karthik Raman, Balagurunathan Kuberan
openaire   +3 more sources

HSPG2 (heparan sulfate proteoglycan 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HSPG2 (heparan sulfate proteoglycan 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Farach-Carson, MC, Grindel, B
openaire   +3 more sources

Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells [PDF]

Circulation Research, 2003
The objective of this study was to test whether a glycosaminoglycan component of the surface glycocalyx layer is a fluid shear stress sensor on endothelial cells (ECs). Because enhanced nitric oxide (NO) production in response to fluid shear stress is a characteristic and physiologically important response of ECs, we evaluated NO
Jason R. Kosky, John M. Tarbell, Zhengyu Pang, Jeffry A. Florian, Randal O. Dull, Kristy M. Ainslie   +5 more
openaire   +3 more sources

Opticin Binds to Heparan and Chondroitin Sulfate Proteoglycans

Investigative Opthalmology & Visual Science, 2005
The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was discovered associated with vitreous humor collagen fibrils. Opticin is present throughout the vitreous, but is particularly concentrated at the internal limiting lamina, where it colocalizes with type XVIII collagen.
Hindson, V. John, Gallagher, John T., Halfter, Willi, Bishop, Paul N.   +3 more
openaire   +4 more sources

Time‐of‐Flight Secondary Ion Mass Spectrometry‐Partial Least Square Regression for Quantifying Interleukin‐8 in Biopolymer Matrices

Advanced NanoBiomed Research, EarlyView.
The power of time‐of‐flight secondary ion mass spectrometry‐partial least square regression to detect interleukin‐8, a chemokine involved in inflammation and cancer, down to mass fractions of 1 ppm within biopolymer matrices, including Matrigel and glycosaminoglycan‐based hydrogels, is demonstrated.
Ralf Zimmermann, Mirko Nitschke, Marten Samulowitz, Nicholas R. Dennison, Carsten Werner   +4 more
wiley   +1 more source

Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide

Glia, EarlyView.
Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel peptide that promotes OL myelin formation. ABSTRACT In the central nervous system, oligodendrocytes (OLs) form myelin sheaths that accomplish the efficient ...
Binri Sasaki, Momo Oishi, Tomoka Aoki, Mai Hyodo, Chinami Onchi, Nanako Yamada, Hitomi Misawa, Momona Yamada, Chikako Hayashi, Kiyotoshi Sekiguchi, Keisuke Hamada, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu, Nobuharu Suzuki   +14 more
wiley   +1 more source

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity [PDF]

Frontiers in Molecular Neuroscience, 2018
Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic partners, and the formation of specific types of synapses.
Giuseppe Condomitti, Giuseppe Condomitti, Joris de Wit, Joris de Wit   +3 more
openaire   +5 more sources

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n 
Lichieh Julie Chu, Chia‐Jung Tsai, Chun‐Chun Chien, Yung‐Chin Hsiao, Jau‐Song Yu, Jun‐Yi Tsai, Ta‐Sen Yeh   +6 more
wiley   +1 more source

Obesity Alters the Vascular Morphology and VEGF‐A Signaling in Adipose Tissue

FASEB BioAdvances, EarlyView.
Obesity alters cell geometry and vessel morphology in mice adipose tissue by increasing adipocyte size by 78% and reducing vessel density by 51%, while vessel size and capillary basement membrane thickness remain unchanged. Obesity also affects angiogenesis, which is mediated by vascular endothelial growth factor (VEGF) binding kinetics.
Yunjeong Lee, Keith Lionel Tukei, Yingye Fang, Shobhan Kuila, Xinming Liu, Princess I. Imoukhuede   +5 more
wiley   +1 more source