Results 51 to 60 of about 17,555 (155)

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

The FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert, Ajaree Mongkolsittisilp, Andrei Kobitski, Matthias Schulz, Oksana Voloshanenko, Meike Schaffrinski, Nadine Winkler, Michelle Neßling, Karsten Richter, Dominique Kranz, Karin Nienhaus, Dirk Jäger, Lorenz Trümper, Judith Büntzel, Claudia Binder, Gerd Ulrich Nienhaus, Michael Boutros   +16 more
wiley   +1 more source

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol

Journal of Neuroendocrinology, EarlyView.
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair, Navdeep S. Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani   +4 more
wiley   +1 more source

Gene Expression Shifts in Emperor Penguin Adaptation to the Extreme Antarctic Environment

Molecular Ecology, EarlyView.
ABSTRACT Gene expression can accelerate ecological divergence by rapidly tweaking the response of an organism to novel environments, with more divergent environments exerting stronger selection and supposedly, requiring faster adaptive responses. Organisms adapted to extreme environments provide ideal systems to test this hypothesis, particularly when ...
Josephine R. Paris, Flávia A. Nitta Fernandes, Federica Pirri, Samuele Greco, Marco Gerdol, Alberto Pallavicini, Marine Benoiste, Clément Cornec, Lorenzo Zane, Brian Haas, Céline Le Bohec, Emiliano Trucchi   +11 more
wiley   +1 more source

Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins

Molecular Microbiology, EarlyView.
A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill, Lara M. Matulina, Cameron MacIntyre, M. Amine Hassani, Sheila Thomas, Matteo Luban, Isabelle Ward, Amina Abdalla, John M. Leong, Brandon L. Garcia, Jacob E. Lemieux   +10 more
wiley   +1 more source

Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans. [PDF]

Front Genet, 2022
Schultheis N, Becker R, Berhanu G, Kapral A, Roseman M, Shah S, Connell A, Selleck S.   +7 more
europepmc   +1 more source

Non‐Anticoagulant Heparin: An In Vitro Investigation of a Novel Therapeutic Approach for Oral Cancer

Oral Diseases, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) represents a significant global oral health concern. Non‐anticoagulant heparin (NH) emerges as a promising solution considering the enhanced survival observed with anticoagulants in cancer treatment. Methods We used the MTS assay (0/24/48/72 h), scratch assay (MuviCyte, 0–18 h), invasion Matrigel (
S. A. Hamza, R. Paolini, N. M. O'Brien‐Simpson, W. Singleton, R. Patini, M. McCullough, A. Celentano   +6 more
wiley   +1 more source

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans. [PDF]

Cancers (Basel), 2023
Hassan N, Efing J, Kiesel L, Bendas G, Götte M.   +4 more
europepmc   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Hemostatic and Nonhemostatic Effects of Heparan Sulfate Proteoglycans [PDF]

Seminars in Thrombosis and Hemostasis, 2021
Yona Nadir, Ton Lisman
openaire   +4 more sources

Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells. [PDF]

Int J Mol Sci, 2022
Takahashi I.
europepmc   +1 more source