Results 51 to 60 of about 20,897 (221)
Heparan Sulfate Proteoglycans in Infection
, 2011 To cause infections, microbial pathogens elaborate a multitude of factors that interact with host components. Using these host–pathogen interactions to their advantage, pathogens attach, invade, disseminate, and evade host defense mechanisms to promote their survival in the hostile host environment.
Pyong Woo Park, Allison H. Bartlett
openaire +2 more sources
Chemical Tumor Biology of Heparan Sulfate Proteoglycans [PDF]
Current Chemical Biology, 2010 Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant ...
Karthik Raman, Balagurunathan Kuberan
openaire +3 more sources
Advanced Functional Materials, EarlyView.This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput +5 more
wiley +1 more source
Glypican-1 drives unconventional secretion of fibroblast growth factor 2
eLife, 2022 Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism.
Carola Sparn +8 more
doaj +1 more source
HSPG2 (heparan sulfate proteoglycan 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HSPG2 (heparan sulfate proteoglycan 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Farach-Carson, MC, Grindel, B
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Advanced Healthcare Materials, EarlyView.Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu +9 more
wiley +1 more source
A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering
Advanced Healthcare Materials, EarlyView.In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng +8 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
doaj +1 more source
Advanced Materials, EarlyView.Understanding the bi‐directional crosstalk between cells and their surrounding extracellular matrix (ECM) is critical for tissue engineering. This study presents a chemoselective strategy for proteomic profiling of newly deposited ECM from resident cells.
Zihan Ling +9 more
wiley +1 more source
Syndecans in Inflammation at a Glance
Frontiers in Immunology, 2020 Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small
Sandeep Gopal
doaj +1 more source