Results 81 to 90 of about 40,174 (273)
Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis
Cells, 2022 Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and its management places a huge burden on healthcare systems through hospitalisation and treatment.
Tien K. Nguyen +6 more
doaj +1 more source
Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action [PDF]
, 2014 Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and ...
Baghy, Kornélia +6 more
core +3 more sources
Heparan sulfate proteoglycans regulate autophagy in Drosophila [PDF]
Autophagy, 2017 Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the cell surface and in the extracellular space. Disruption of HSPG core proteins, HS-synthesis, or HS-degradation can have profound effects on growth, patterning, and cell survival.
Reynolds-Peterson, Claire E. +5 more
openaire +2 more sources
Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
Medical Sciences, 2019 Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease.
Giulia Furini, Elisabetta A.M. Verderio
doaj +1 more source
Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes [PDF]
, 2010 Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core +1 more source
Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]
, 2017 Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid +16 more
core +1 more source
Chemical Tumor Biology of Heparan Sulfate Proteoglycans [PDF]
Current Chemical Biology, 2010 Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant ...
Karthik, Raman, Balagurunathan, Kuberan
openaire +2 more sources
3D Hydrogel Cell Cultures and Their Biomedical Applications
Advanced NanoBiomed Research, EarlyView.The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai +7 more
wiley +1 more source
Proteinase activity regulation by glycosaminoglycans [PDF]
, 2002 There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and glycosaminoglycans is able to modulate
Almeida, P.c. +3 more
core +3 more sources