Results 71 to 80 of about 205,561 (359)

Hepatic fibrogenesis requires sympathetic neurotransmitters [PDF]

, 2004
Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear.
Diehl, AM, Huang, J, Li, Z, Lin, H, Moran, TH, Oben, JA, Roskams, T, Sinelli, N, Smedh, U, Thomas, SA, Torbenson, M, Yang, S   +11 more
core   +2 more sources

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Didymin Alleviates Hepatic Fibrosis Through Inhibiting ERK and PI3K/Akt Pathways via Regulation of Raf Kinase Inhibitor Protein

Cellular Physiology and Biochemistry, 2016
Background: Didymin has been reported to have anti-cancer potential. However, the effect of didymin on liver fibrosis remains illdefined. Methods: Hepatic fibrosis was induced by CCl4 in rats.
Xing Lin, Faicheng Bai, Jinlan Nie, Shengjuan Lu, Chunyuang Lu, Xunshuai Zhu, Jinbin Wei, Zhongpeng Lu, Quanfang Huang   +8 more
doaj   +1 more source

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood.
Xiaolin Zhong, Menghao Huang, Hyeong-Geug Kim, Yang Zhang, Kushan Chowdhury, Wenjie Cai, Romil Saxena, Robert F. Schwabe, Suthat Liangpunsakul, X. Charlie Dong   +9 more
doaj   +1 more source

In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A

Scientific Reports, 2018
Clinical studies have found that moderate intake of retinol or oleic acid can enlarge the lipid droplets of hepatic stellate cells and suppress their activation. However, the link between lipid droplets and cell activation is unknown. This study compared
Yun Hong, Sirui Li, Jifeng Wang, Youming Li   +3 more
semanticscholar   +1 more source

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Heliyon
Background: Hepatic fibrosis is caused by various liver diseases and eventually develops into liver cancer. There is no specific drug approved for the treatment of hepatic fibrosis in the world.
Xue Hu, Haotian Shen, Rong Liu, Bin Tang, Fengmei Deng   +4 more
doaj   +1 more source

Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice

Frontiers in Nutrition, 2022
BackgroundActivation of hepatic stellate cells (HSCs) is essential for the pathogenesis of liver fibrosis, there is no effective drug used to prevent or reverse the fibrotic process.MethodsWith human hepatic stellate cell line LX-2 and mouse model of ...
Qianyuan Gong, Zhaoyu Zeng, Tao Jiang, Xue Bai, Chunlan Pu, Yaying Hao, Yuanbiao Guo   +6 more
doaj   +1 more source

Human hepatic stellate cell isolation and characterization

Journal of gastroenterology, 2017
The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis.
Linshan Shang, M. Hosseini, Xiao Liu, T. Kisseleva, D. Brenner   +4 more
semanticscholar   +1 more source