Results 1 to 10 of about 210,456 (335)

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +2 more sources

Hepatic stellate cells and parasite-induced liver fibrosis [PDF]

Parasites & Vectors, 2010
Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Li Yuesheng S, Allen Jeremy T, Anthony Barrie, McManus Donald P   +3 more
doaj   +4 more sources

Hepatic Stellate Cells and Hepatocarcinogenesis

Frontiers in Cell and Developmental Biology, 2020
Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation ...
Anna E. Barry, Anna E. Barry, Rajkumar Baldeosingh, Rajkumar Baldeosingh, Ryan Lamm, Keyur Patel, Kai Zhang, Kai Zhang, Dana A. Dominguez, Kayla J. Kirton, Ashesh P. Shah, Hien Dang, Hien Dang   +12 more
doaj   +2 more sources

MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia [PDF]

European Journal of Medical Research
Background Biliary atresia (BA) is one of the most common liver diseases in infants and young children. Its etiology and pathogenesis are still unclear.
Xilin Liao, Rui Liu, Teng Zhou, Xiaohuan Zhao, Xiangang Xiong, Kaizhi Zhang, Zebing Zheng, Xingrong Xia, Chengyan Tang, Yuan Gong, Qing Du, Lu Huang, Daiwei Zhu, Wankang Zhou, Yuanmei Liu, Zhu Jin   +15 more
doaj   +2 more sources

Thrombin and factor Xa link the coagulation system with liver fibrosis

BMC Gastroenterology, 2018
Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated.
Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, Mark R. Thursz   +5 more
doaj   +2 more sources

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells [PDF]

Hepatology, 2017
Francesca Virginia Bruschi, Thierry Claudel, Matteo Tardelli, Alessandra Caligiuri, Thomas M. Stulnig, Fabio Marra, Michael Trauner   +6 more
openalex   +2 more sources

Hepatic stellate cells in physiology and pathology

Journal of Physiology, 2022
Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury.
Dakota R. Kamm, K. McCommis
semanticscholar   +1 more source

Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

Science immunology, 2022
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although the mechanisms of SASP factor induction have been intensively studied, the release mechanism and how SASP factors influence tumorigenesis ...
Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, S. Yamazaki, Tomonori Kamiya, M. Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa-Muto, L. Thuy, Yohsuke Harada, T. Arai, Tze Mun Loo, S. Yoshimoto, T. Ando, M. Nakajima, H. Taguchi, Takamasa Ishikawa, H. Akiba, S. Miyake, M. Kubo, Y. Iwakura, Shinji Fukuda, Wei‐Yu Chen, N. Kawada, A. Rudensky, S. Nakae, Eiji Hara, Naoko Ohtani   +28 more
semanticscholar   +1 more source

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +1 more source

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression

Cells, 2022
Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained from 50
Pramudi Wijayasiri, S. Astbury, Philip Kaye, F. Oakley, G. Alexander, T. Kendall, A. Aravinthan   +6 more
semanticscholar   +1 more source