Results 1 to 10 of about 70,155 (185)

Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts [PDF]

BMC Cell Biology, 2000
Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver.
Kunz Dagmar, van de Leur Eddy, Weiskirchen Sabine, Kneifel Jens, Weiskirchen Ralf, Gressner Axel M   +5 more
doaj   +3 more sources

Hepatic Stellate Cells and Hepatocarcinogenesis [PDF]

Frontiers in Cell and Developmental Biology, 2020
Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation ...
Anna E. Barry, Anna E. Barry, Rajkumar Baldeosingh, Rajkumar Baldeosingh, Ryan Lamm, Keyur Patel, Kai Zhang, Kai Zhang, Dana A. Dominguez, Kayla J. Kirton, Ashesh P. Shah, Hien Dang, Hien Dang   +12 more
doaj   +3 more sources

MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia [PDF]

European Journal of Medical Research
Background Biliary atresia (BA) is one of the most common liver diseases in infants and young children. Its etiology and pathogenesis are still unclear.
Xilin Liao, Rui Liu, Teng Zhou, Xiaohuan Zhao, Xiangang Xiong, Kaizhi Zhang, Zebing Zheng, Xingrong Xia, Chengyan Tang, Yuan Gong, Qing Du, Lu Huang, Daiwei Zhu, Wankang Zhou, Yuanmei Liu, Zhu Jin   +15 more
doaj   +2 more sources

Thrombin and factor Xa link the coagulation system with liver fibrosis

BMC Gastroenterology, 2018
Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated.
Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, Mark R. Thursz   +5 more
doaj   +2 more sources

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +1 more source

β-arrestin1 activates hepatic stellate cells to promote liver fibrosis via activating p38 signaling pathway [PDF]

Xin yixue, 2023
Objective To investigate the role ofβ-arrestin1 （ARRB1） in liver fibrosis and elucidate the mechanism of hepatic stellate cell activation induced by ARRB1/p38 signaling pathway to promote liver fibrosis.
Xia Yanhao, Liu Huiling, Jiang Jie, Wu Bin
doaj   +1 more source

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +1 more source

Hydrostatic pressure induces profibrotic properties in hepatic stellate cells via the RhoA/ROCK signaling pathway

FEBS Open Bio, 2022
Elevated interstitial fluid hydrostatic pressure is commonly observed in diseased livers. We herein examined the hypothesis that hydrostatic pressure induces hepatic stellate cells to acquire profibrotic properties under pathological conditions.
Zisheng Huang, Mahmoud Osman Khalifa, Weili Gu, Tao‐Sheng Li   +3 more
doaj   +1 more source

Liver fibrosis is driven by protease‐activated receptor‐1 expressed by hepatic stellate cells in experimental chronic liver injury

Research and Practice in Thrombosis and Haemostasis, 2020
Background Blood coagulation protease activity is proposed to drive hepatic fibrosis through activation of protease‐activated receptors (PARs). Whole‐body PAR‐1 deficiency reduces experimental hepatic fibrosis, and in vitro studies suggest a potential ...
Lauren G. Poole, Asmita Pant, Holly M. Cline‐Fedewa, Kurt J. Williams, Bryan L. Copple, Joseph S. Palumbo, James P. Luyendyk   +6 more
doaj   +1 more source

Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation

BMJ Open Gastroenterology, 2023
Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz, Detlef Schuppan, Pietro Di Fazio, Sophia Mielke, Isabell T Böhm, Sami Matrood, Thaddeus Wissniowski   +6 more
doaj   +1 more source