Results 131 to 140 of about 210,456 (335)
The roles of microRNA families in hepatic fibrosis
Cell & Bioscience, 2017 When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang +4 more
doaj +1 more source
Advanced Science, EarlyView.This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang +13 more
wiley +1 more source
Endocannabinoid-related compounds in gastrointestinal diseases [PDF]
, 2018 The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro +7 more
core +1 more source
Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
Advanced Science, EarlyView.This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen +14 more
wiley +1 more source
Cancer Research, 2018 Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma (HCC), which usually develops from fibrotic liver.
Yuki Makino +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu +12 more
wiley +1 more source
Autophagy, 2018 Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, the molecular mechanisms regulating ferroptosis are largely unknown.
Zili Zhang +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu +8 more
wiley +1 more source
Expression and mechanism of gp73 in liver tissue of mouse liver fibrosis [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the changes and mechanism of golgi protein 73 (gp73) in mouse with liver fibrosis. Methods The model of hepatic fibrosis was developed by intraperitoneal injection of CCl4 in C57BL6/J mice.
MA Ling-yu, ZHEN Yi-ning, LUO Yun-ping, DUAN Zhao-jun
doaj
Toll–Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells [PDF]
, 2003 Yong‐Han Paik +5 more
openalex +1 more source