Results 151 to 160 of about 79,018 (355)

Id1 is a critical mediator in TGF-β–induced transdifferentiation of rat hepatic stellate cells [PDF]

, 2006
Eliza Wiercinska, L Wickert, Bernd Denecke, Harun M. Said, Jafar Hamzavi, Axel M. Gressner, Midori Thorikay, Peter ten Dijke, Peter R. Mertens, K Breitkopf, Steven Dooley   +10 more
openalex   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Hepatitis B virus X protein activates human hepatic stellate cells through upregulating TGFβ1

, 2014
H.-Y. Chen, Ziguo Chen, Renfang Huang, Ning Lin, Xin‐Yao Wang   +4 more
openalex   +1 more source

Periostin down‐regulation attenuates the pro‐fibrogenic response of hepatic stellate cells induced by TGF‐β1 [PDF]

, 2015
Hong Li, Dai Shejiao, Chen Fenrong, Gang Zhao, Lei Dong   +4 more
openalex   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. [PDF]

, 2015
Background&aimsHepatic stellate cells (HSCs) play a key role in liver fibrosis in various chronic liver disorders including nonalcoholic fatty liver disease (NAFLD).
Alisi, Anna, de Araujo Horcel, Lucas, Eguchi, Akiko, Feldstein, Ariel E, Johnson, Casey D, Nobili, Valerio, Panera, Nadia, Papouchado, Bettina G, Pinatel, Eva M, Povero, Davide   +9 more
core  

Enzyme‐Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe

Advanced Science, EarlyView.
Enzyme‐activated MRI (eaMRI) using a biodegradable CrGOx@Lip nanoprobe enables glucose‐specific imaging in vivo. GOx catalyzes glucose oxidation, triggering in situ formation of paramagnetic chromium gluconate and amplifying T1. This radiation‐free strategy maps tumor glucose uptake via the Warburg‐effect, quantifies hepatic glucose accumulation in ...
Yan Xu, Weitao Yang, Yanjing Yun, Hui Wang, Zhuoyao Wu, Youyi Yu, Bingbo Zhang   +6 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Gene polymorphisms in primary biliary cirrhosis: association with the disease and hepatic osteopathy [PDF]

, 2007
Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC). Estrogen receptor-alpha gene (ER- ), vitamin-D-receptor gene (VDR) and IL-1-receptor-antagonist gene (IL-1RN) are all ...
Bajnok, Éva, Ferenci, Péter, Lakatos, Péter, Lakatos, Péter László, Szalay, Ferenc, Takács, István, Willheim-Polli, Claudia   +6 more
core  

Signal transduction involved in activation of hepatic stellate cells

, 2015
REN Changzhen
openalex   +2 more sources