Results 11 to 20 of about 20,970 (205)
Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA [PDF]
Journal of Virology, 1990 It has previously been shown that human hepatitis virus delta antigen has an RNA-binding activity (Chang et al., J. Virol. 62:2403-2410, 1988). In the present study, the specificity of such an RNA-protein interaction was demonstrated by expressing various domains of the delta antigen in Escherichia coli as TrpE fusion proteins and testing their RNA ...
J H, Lin +4 more
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Hepatitis Delta Antigen Mediates the Nuclear Import of Hepatitis Delta Virus RNA [PDF]
Journal of Virology, 1998 ABSTRACT Hepatitis delta virus (HDV) RNA replicates in the nuclei of virus-infected cells. The mechanism of nuclear import of HDV RNA is so far unknown. Using a fluorescein-labeled HDV RNA introduced into partially permeabilized HeLa cells, we found that HDV RNA accumulated only in the cytoplasm.
H C, Chou +3 more
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A novel form of hepatitis delta antigen [PDF]
Journal of Virology, 1996 Hepatitis delta virus (HDV) is known to express a protein termed the small delta antigen, a structural protein which is also essential for genome replication. During replication, posttranscriptional RNA editing specifically modifies some of the HDV RNA, leading to the production of an elongated form of the delta antigen, the large form, which is ...
V V, Bichko, Y E, Khudyakov, J M, Taylor
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Phosphorylation of the hepatitis delta virus antigens [PDF]
Journal of Virology, 1997 We used two-dimensional electrophoresis (nonequilibrium pH gradient electrophoresis followed by sodium dodecyl sulfate-10% polyacrylamide gel electrophoresis) coupled with 32P labeling and immunoblotting detection with 125I-protein A to detect and quantitate phosphorylation of the large and small forms of the delta antigen (deltaAg-L and deltaAg-S ...
V, Bichko, S, Barik, J, Taylor
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Virology Journal, 2022 Background Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis.
Wei-Chung Chiou +7 more
doaj +1 more source
Genotype-Specific Complementation of Hepatitis Delta Virus RNA Replication by Hepatitis Delta Antigen [PDF]
Journal of Virology, 1998 ABSTRACT Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype.
J L, Casey, J L, Gerin
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Distinct histological patterns in chronic hepatitis D with nucleos(t)ide analogue therapy
Frontiers in Medicine, 2023 BackgroundChronic hepatitis delta virus (HDV) infection leads to a more severe hepatitis than hepatitis B virus (HBV) infection alone. Specific histological staining patterns have been described in HBV mono-infection, however this has not been ...
Julian Hercun +4 more
doaj +1 more source
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
core +2 more sources
Viruses, 2021 Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, but little is known about the molecular mechanisms involved. We have recently developed an HDV mouse model based on the delivery of HDV replication-competent genomes ...
Sheila Maestro +8 more
doaj +1 more source
Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]
, 2005 CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Bertoletti, A. +6 more
core +2 more sources