Extracellular Vesicles in the Development of the Non-Alcoholic Fatty Liver Disease: An Update
Biomolecules, 2020 Non-alcoholic fatty liver disease (NAFLD) is a broad spectrum of liver damage disease from a simple fatty liver (steatosis) to more severe liver conditions such as non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Extracellular vesicles (EVs)
Vicneswarry Dorairaj +3 more
doaj +1 more source
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +5 more sources
Cells, 2020 (1) Background: Platelets were postulated to constitute the trigger of liver regeneration. The aim of this study was to dissect the cellular interactions between the various liver cells involved in liver regeneration and to clarify the role of platelets.
Jeremy Meyer +7 more
doaj +1 more source
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]
, 2009 HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher +47 more
core +3 more sources
Clinical hepatocyte transplantation [PDF]
Gastroenterología y Hepatología, 2018 A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation. Hepatocyte transplantation has been proposed as an alternative therapeutic approach for liver disease patients to address this urgent and unmet medical need.
openaire +2 more sources
Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]
, 2008 Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H. +10 more
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Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI
Journal of Lipid Research, 2012 To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice.
Ailing Ji +5 more
doaj +1 more source
HISTOLOGICAL AND HISTOCHEMICAL STUDY OF THE LIVER OF IRAQI LOCAL DUCKS [PDF]
Basrah Journal of Veterinary Research, 2015 The aim of study is provide basic data about the histological features of the liver of local Iraqi ducks and to study the glycogen content in the cytoplasm of the hepatocyte.
Maha Abd Al- Hadi Al- Abdulla
doaj +1 more source
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. [PDF]
, 2019 The decrease in incretin effects is an important etiologic component of type 2 diabetes with unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1α expression was increased mainly ...
Bandyopadhyay, Guatam K +3 more
core
Galectin-1 is essential for efficient liver regeneration following hepatectomy [PDF]
, 2016 Galectin-1 (Gal1) is a known immune/inflammatory regulator which actsboth extracellularly and intracellularly, modulating innate and adaptive immuneresponses. Here, we explored the role of Gal1 in liver regeneration using 70% partial hepatectomy (PHx) of
Cerliani, Juan Pablo +7 more
core +1 more source