Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source
Quantification of Nematic Cell Polarity in Three-dimensional Tissues [PDF]
, 2020 How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polarity ...
Brusch, Lutz +11 more
core +3 more sources
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]
, 2019 Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura +8 more
core +1 more source
Hepatocyte Differentiation [PDF]
, 2010 Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak +2 more
openaire +2 more sources
Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]
, 2017 Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha +5 more
core +2 more sources
Journal of Lipid Research, 2013 Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low.
Thomas Gautier +16 more
doaj +1 more source
Food Innovation and Advances, 2023 Ferroptosis is a distinct form of cell death that is driven by iron-dependent phospholipid peroxidation. Polyunsaturated fatty acids (PUFAs), particularly arachidonic acid (AA) and adrenal acid (AdA), are most prone to lipid peroxidation, which induces ...
Han Zhang +5 more
doaj +1 more source
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources
Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors [PDF]
, 1992 Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast,
Alessandro Azzarone +28 more
core +1 more source
Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration
Nature, 2017 After liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver injury, hepatocyte proliferation is impaired—a feature of human chronic liver disease.
A. Raven +13 more
semanticscholar +1 more source