Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases [PDF]
BMC Medicine, 2021 Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions.
Nurdan Guldiken +17 more
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Animal, 2010 The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
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Hepatocyte Nuclear Factor 1α: A Key Mediator of the Effect of Bile Acids on Gene Expression [PDF]
Hepatology, 2003 Bile acids regulate the expression of genes involved in cholesterol homeostasis. They are ligands of the farnesoid X receptor, which induces small heterodimer partner (SHP)–1, a transcriptional repressor of bile acid synthetic enzymes.
Jung Diana, Kullak-Ublick Gerd A
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Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. [PDF]
Sci Rep, 2020 AbstractHepatocyte nuclear factor 1 homeobox alpha (HNF1α) is a transcription factor involved in endodermal organogenesis and pancreatic precursor cell differentiation and development. Earlier studies have reported a role for HNF1α in pancreatic ductal adenocarcinoma (PDAC) but it is controversial.
Subramani R +10 more
europepmc +4 more sources
Hepatocellular Adenoma With Hepatocyte Nuclear Factor-1 Alpha (HNF-1α) Mutation: A Case Report. [PDF]
CureusHepatocellular adenoma (HCA) is an uncommon benign liver tumor that exhibits a variety of subtypes, each distinguished by unique molecular alterations. This case report describes a 43-year-old man with a history of alcoholism who presented with stomach pain.
Moliya P +4 more
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Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young [PDF]
Diabetologia, 2002 Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations.
M P, Bulman +6 more
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Hepatocyte Nuclear Factor-1α Gene Mutations and Diabetes in Norway [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2003 Mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene cause maturity-onset diabetes of the young (MODY), type 3. To estimate the prevalence of MODY3 in Norwegian diabetic pedigrees, we screened a total of 130 families for HNF-1 alpha mutations; 42 families with clinical MODY, 75 with suspected MODY, and 13 pedigrees with multiplex type 1 ...
Lise, Bjørkhaug +5 more
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HNF4A (Hepatocyte Nuclear Factor 4 alpha) [PDF]
, 2017 Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (Nuclear Receptor Subfamily 2, group A, member 1) is a member of the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. The encoded protein controls the expression of
Banerjee, Sreeparna, Tunçer, Sinem
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Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma
Case Reports in Gastroenterology, 2020 Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen.
Joris T. Hepkema +6 more
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Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]
, 2008 DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F. +14 more
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