Results 21 to 30 of about 34,122,793 (250)

The role of hepatocyte growth factor/scatter factor in hepatoblastoma and hepatocellular carcinoma progression [PDF]

, 2006
Hepatocyte growth factor/scatter factor (HGF/SF) is a ubiquitously expressed molecule that elicits pleiotropic functions on epithelial cells, including mitogenic, motogenic, differentiating, angiogenic, and morphogenic effects. The receptor for HGF/SF is
Grotegut, Stefan
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Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells [PDF]

, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival.
Krishnamachary, B., Guus M. Bol, Paul T Winnard, Paul T. Winnard, Vesuna, F., Patel, A.H., Botlagunta, M., Mahendran Botlagunta, Farhad Vesuna, Ramanathan, V., Venu Raman, Arvind H Patel, Arvind H. Patel, Winnard, P.T., Bol, G.M., Guus M Bol, Balaji Krishnamachary   +16 more
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Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives

Frontiers in Endocrinology, 2018
Diabetes is a global epidemic problem growing exponentially in Asian countries posing a serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction ...
Parveena Firdous, Kamran Nissar, Sajad Ali, Bashir Ahmad Ganai, Uzma Shabir, Toyeeba Hassan, Shariq Rashid Masoodi   +6 more
doaj   +1 more source

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. [PDF]

, 1998
The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis factor-alpha (TNF-alpha) by HBV-infected hepatocytes is ...
Armesilla, Angel, Redondo, Juan Miguel, Lara-Pezzi, Enrique, Juan Miguel Redondo, López-Cabrera, Manuel, Pedro L. Majano, Armesilla, Angel L., Enrique Lara-Pezzi, Angel Luis Armesilla, Majano, Pedro L., Manuel López-Cabrera, Redondo, Juan M.   +11 more
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Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus [PDF]

, 2016
Rabbitfish Siganus canaliculatus was the first marine teleost demonstrated to have the capability of biosynthesizing long-chain polyunsaturated fatty acids (LC-PUFA) from C18 precursors, and to possess a Δ4 fatty acyl desaturase (Δ4 Fad ...
You, Cuihong, Monroig, Oscar, Tocher, Douglas R, Chen, Fang, Dong, Yewei, Wang, Shuqi, Li, Yuanyou, Liu, Fang   +7 more
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HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression

Journal of Hematology & Oncology, 2020
Background Aerobic glycolysis is a hallmark of metabolic reprogramming that contributes to tumor progression. However, the mechanisms regulating expression of glycolytic genes in neuroblastoma (NB), the most common extracranial solid tumor in childhood ...
Huajie Song, Dan Li, Xiaojing Wang, Erhu Fang, Feng Yang, Anpei Hu, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Yajun Chen, Kai Huang, Liduan Zheng, Qiangsong Tong   +13 more
doaj   +1 more source

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Frontiers in Pharmacology, 2017
Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet, Adrien Labriet, Elena De Mattia, Erika Cecchin, Éric Lévesque, Éric Lévesque, Derek Jonker, Félix Couture, Félix Couture, Angela Buonadonna, Mario D’Andrea, Lyne Villeneuve, Lyne Villeneuve, Giuseppe Toffoli, Chantal Guillemette, Chantal Guillemette   +15 more
doaj   +1 more source

Transcriptional Regulation of the Beta-Synuclein 5′-Promoter Metal Response Element by Metal Transcription Factor-1 [PDF]

, 2011
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh, David R. Brown, Josephine A. Wright, McHugh, Patrick C, Wright, Josephine A., Josephine A Wright, Wright Josephine A., Brown David R., David R Brown, McHugh Patrick C., Brown, David R., Patrick C. McHugh   +11 more
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Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed, Susan Elkholy, Ebtessam El-Meleagy, Khaled Abu-Amero, Ali M. Hellani   +4 more
doaj   +1 more source

Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans. [PDF]

PLoS ONE, 2014
Glomerular nodular lesions, known as Kimmelstiel-Wilson nodules, are a pathological hallmark of progressive human diabetic nephropathy. We have induced severe diabetes in pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (HNF1α ...
Satoshi Hara, Kazuhiro Umeyama, Takashi Yokoo, Hiroshi Nagashima, Michio Nagata   +4 more
doaj   +1 more source