Results 21 to 30 of about 42,925 (253)

Mutation of TCF1 encoding hepatocyte nuclear factor 1α in gynecological cancer [PDF]

Oncogene, 2004
TCF1: (transcription factor 1) encoding hepatocyte nuclear factor 1alpha (HNF1alpha) is mutated in 50% of liver cell adenomas, a benign tumor closely associated with oral contraceptive use. These genetic alterations inactivate both alleles, leading to the absence of wild-type HNF1alpha expression in liver cell adenomas.
Rebouissou, Sandra, Rosty, Christophe, Lecuru, Fabrice, Boisselier, Sophie, Bui, Hung, Le Frere-Belfa, Marie-Aude, Sastre, Xavier, Laurent-Puig, Pierre, Zucman-Rossi, Jessica   +8 more
openaire   +5 more sources

Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives

Frontiers in Endocrinology, 2018
Diabetes is a global epidemic problem growing exponentially in Asian countries posing a serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction ...
Parveena Firdous, Kamran Nissar, Sajad Ali, Bashir Ahmad Ganai, Uzma Shabir, Toyeeba Hassan, Shariq Rashid Masoodi   +6 more
doaj   +1 more source

HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression

Journal of Hematology & Oncology, 2020
Background Aerobic glycolysis is a hallmark of metabolic reprogramming that contributes to tumor progression. However, the mechanisms regulating expression of glycolytic genes in neuroblastoma (NB), the most common extracranial solid tumor in childhood ...
Huajie Song, Dan Li, Xiaojing Wang, Erhu Fang, Feng Yang, Anpei Hu, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Yajun Chen, Kai Huang, Liduan Zheng, Qiangsong Tong   +13 more
doaj   +1 more source

Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver [PDF]

The Pharmacogenomics Journal, 2007
Experimental evidence suggests HNF1alpha regulates UGT expression. This study investigates (1) whether the variability in HNF1alpha expression is associated with the variability in UGT1A1, UGT1A9 and UGT2B7 expression in human livers and (2) the functionality of 12 HNF1alpha variants using mRNA expression as phenotype.
J, Ramírez, S, Mirkov, W, Zhang, P, Chen, S, Das, W, Liu, M J, Ratain, F, Innocenti   +7 more
openaire   +2 more sources

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Frontiers in Pharmacology, 2017
Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet, Adrien Labriet, Elena De Mattia, Erika Cecchin, Éric Lévesque, Éric Lévesque, Derek Jonker, Félix Couture, Félix Couture, Angela Buonadonna, Mario D’Andrea, Lyne Villeneuve, Lyne Villeneuve, Giuseppe Toffoli, Chantal Guillemette, Chantal Guillemette   +15 more
doaj   +1 more source

Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1α [PDF]

Biochemical Journal, 1999
Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the expression of dipeptidyl peptidase IV in the human intestinal and hepatic epithelial cell lines Caco-2 and HepG2.
R H, Erickson, J R, Gum, C D, Lotterman, J W, Hicks, R S, Lai, Y S, Kim   +5 more
openaire   +2 more sources

Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed, Susan Elkholy, Ebtessam El-Meleagy, Khaled Abu-Amero, Ali M. Hellani   +4 more
doaj   +1 more source

MODY: Strategies for a unique form of diabetes

Journal of Education and Health Promotion
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj   +1 more source

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

BMC Medicine, 2021
Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions.
Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz, Ramon Bataller, Pavel Strnad   +17 more
doaj   +1 more source

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins. [PDF]

PLoS ONE, 2016
Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy.
Masaaki Watanabe, Helen Zemack, Helene Johansson, Louise Hagbard, Carl Jorns, Meng Li, Ewa Ellis   +6 more
doaj   +1 more source