Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver [PDF]
The Pharmacogenomics Journal, 2007 Experimental evidence suggests HNF1alpha regulates UGT expression. This study investigates (1) whether the variability in HNF1alpha expression is associated with the variability in UGT1A1, UGT1A9 and UGT2B7 expression in human livers and (2) the functionality of 12 HNF1alpha variants using mRNA expression as phenotype.
J, Ramírez +7 more
openaire +2 more sources
Frontiers in Pharmacology, 2017 Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet +15 more
doaj +1 more source
Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans. [PDF]
PLoS ONE, 2014 Glomerular nodular lesions, known as Kimmelstiel-Wilson nodules, are a pathological hallmark of progressive human diabetic nephropathy. We have induced severe diabetes in pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (HNF1α ...
Satoshi Hara +4 more
doaj +1 more source
Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1α [PDF]
Biochemical Journal, 1999 Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the expression of dipeptidyl peptidase IV in the human intestinal and hepatic epithelial cell lines Caco-2 and HepG2.
R H, Erickson +5 more
openaire +2 more sources
Annals of Saudi Medicine, 2014 BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed +4 more
doaj +1 more source
MODY: Strategies for a unique form of diabetes
Journal of Education and Health PromotionMaturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj +1 more source
The role of hepatocyte growth factor/scatter factor in hepatoblastoma and hepatocellular carcinoma progression [PDF]
, 2006 Hepatocyte growth factor/scatter factor (HGF/SF) is a ubiquitously expressed molecule that elicits pleiotropic functions on epithelial cells, including mitogenic, motogenic, differentiating, angiogenic, and morphogenic effects. The receptor for HGF/SF is
Grotegut, Stefan
core +1 more source
Regulation of transthyretin and hepatocyte nuclear factor three beta gene expression in the liver.
, 1997 Regulation of transthyretin and hepatocyte nuclear factor three beta gene expression in the ...
Uzma. Samadani (7983734)
core +5 more sources
Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins. [PDF]
PLoS ONE, 2016 Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy.
Masaaki Watanabe +6 more
doaj +1 more source
, 1994 Functional characterization and regulation of liver transcription factors hepatocyte nuclear factor ...
Xiaobing. Qian (8000012)
core +5 more sources