Results 231 to 240 of about 993,672 (387)

Hepatocyte Nuclear Factor-4α Involved in Type 1 Maturity-Onset Diabetes of the Young Is a Novel Target of AMP-Activated Protein Kinase [PDF]

, 2001
Isabelle Leclerc, Claudia Lenzner, Laurence Gourdon, Sophie Vaulont, Axel Kahn, Benoı̂t Viollet   +5 more
openalex   +1 more source

Hepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review

Animal Research and One Health, EarlyView.
phosphoenolpyruvate carboxy kinase, FBP1, and glucose‐6‐phosphatase are key rate‐limiting enzymes that determine the efficiency of gluconeogenesis. The main substrate for gluconeogenesis in the liver of ruminants is propionate, which provides more than 60% of the carbon source for gluconeogenesis.
Guoyan Wang, Yuanyuan Zhu, Dingping Feng, Junhu Yao, Yangchun Cao, Lu Deng   +5 more
wiley   +1 more source

MODY3 and Pancreatic Transplant: Making a Case for Universal MODY Screening Before Transplant

AACE Clinical Case Reports, 2015
: Objective: Maturity onset diabetes of the young (MODY) comprise a group of autosomal dominant forms of diabetes and account for approximately 1 to 2% of diabetes.
Priyathama Vellanki, MD, Jessica Hwang, MD, Louis H. Philipson, MD, PhD, Brian T. Layden, MD, PhD   +3 more
doaj  

Purification and biochemical characterization of hepatocyte nuclear factor 2 involved in liver-specific transcription of the human alpha 1-antitrypsin gene.

, 1990
Vangipuram S. Rangan, Gautam Das
openalex   +1 more source

Maturity-Onset Diabetes of the Young Type 1 (MODY1)-Associated Mutations R154X and E276Q in Hepatocyte Nuclear Factor 4α (HNF4α) Gene Impair Recruitment of p300, a Key Transcriptional Coactivator [PDF]

, 2001
Jérôme Eeckhoute, Pierre Formstecher, Bernard Laine   +2 more
openalex   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Supplementary Table 1 from Association of CYP1B1 Germ Line Mutations with Hepatocyte Nuclear Factor 1α–Mutated Hepatocellular Adenoma [PDF]

, 2023
Emmanuelle Jeannot, Karine Poussin, L. Chiche, Yannick Bacq, Nathalie Stürm, Jean‐Yves Scoazec, Catherine Buffet, Jeanne Tran Van Nhieu, Christine Bellanné‐Chantelot, Claudia de Toma, Pierre Laurent‐Puig, Paulette Bioulac‐Sage, Jessica Zucman‐Rossi   +12 more
openalex   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells [PDF]

, 2002
Qin Yang, Kazuya Yamagata, Kenji Fukui, Yang Cao, Takao Nammo, Hiromi Iwahashi, Haiyan Wang, Itaru Matsumura, Toshiaki Hanafusa, Richard Bucala, Claes B. Wollheim, Jun-ichiro Miyagawa, Yūji Matsuzawa   +12 more
openalex   +1 more source