Results 51 to 60 of about 136,980 (341)
Evaluation of relationship between HNF-1α and GLP-1R polymorphisms and type 2 diabetes in a population living in northeast of Iran [PDF]
Journal of Cell and Molecular Research, 2013 The prevalence of type 2 diabetes mellitus (T2DM) is rising dramatically in the Middle East, especially in the Islamic Republic of Iran, but the genetic basis of type 2 diabetes in Iran is poorly understood. Polymorphisms of hepatocyte nuclear factor-1α (
Samaneh Sepahi +4 more
doaj +1 more source
The regulatory landscape of retinoblastoma: a pathway analysis perspective
Royal Society Open Science, 2022 Retinoblastoma (Rb) is a rare intraocular tumour in early childhood, with an approximate incidence of 1 in 18 000 live births. Experimental studies for Rb are complex due to the challenges associated with obtaining a normal retina to contrast with ...
Laura Gómez-Romero +4 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed
Jingxin Mao +4 more
doaj +1 more source
Diabetology & Metabolic Syndrome, 2022 Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali +11 more
doaj +1 more source
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]
, 2015 Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang +10 more
core +3 more sources
Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma
Case Reports in Gastroenterology, 2020 Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen.
Joris T. Hepkema +6 more
doaj +1 more source
Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]
, 2014 The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core +1 more source
Structure of the gene enconding hepatocyte nuclear factor 1 (HNF1)
Nucleic Acids Research, 1992 Genomic clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the liver in a tissue-specific manner. We have determined the intron/exon structure of the HNF1 gene, which is strictly conserved between rat and mouse and ...
I, Bach, M, Pontoglio, M, Yaniv
openaire +3 more sources
MODY: Strategies for a unique form of diabetes
Journal of Education and Health PromotionMaturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj +1 more source
Journal of Lipid Research, 2019 All-trans retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A repression is suggested as a driver. However, the underlying molecular mechanisms
Kyoung-Jae Won +2 more
doaj +1 more source