Results 51 to 60 of about 993,672 (387)

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

Cell Reports, 2023
Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored.
Rebekka Lambrecht, M. Eugenia Delgado, Vincent Gloe, Karina Schuetz, Anna Pia Plazzo, Barbara Franke, Truong San Phan, Jennifer Fleming, Olga Mayans, Thomas Brunner   +9 more
doaj  

Structure of the gene enconding hepatocyte nuclear factor 1 (HNF1)

Nucleic Acids Research, 1992
Genomic clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the liver in a tissue-specific manner. We have determined the intron/exon structure of the HNF1 gene, which is strictly conserved between rat and mouse and ...
Marco Pontoglio, Ingolf Bach, Moshe Yaniv   +2 more
openaire   +4 more sources

Evaluation of relationship between HNF-1α and GLP-1R polymorphisms and type 2 diabetes in a population living in northeast of Iran [PDF]

Journal of Cell and Molecular Research, 2013
The prevalence of type 2 diabetes mellitus (T2DM) is rising dramatically in the Middle East, especially in the Islamic Republic of Iran, but the genetic basis of type 2 diabetes in Iran is poorly understood. Polymorphisms of hepatocyte nuclear factor-1α (
Samaneh Sepahi, Razieh Jalal, Behnaz Toluinia, Ahamad Asoodeh, Jamshid Darvish   +4 more
doaj   +1 more source

Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity‐Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia

Human Mutation, 2013
Maturity‐onset diabetes of the young (MODY) is a monogenic disorder characterized by autosomal dominant inheritance of young‐onset (typically
K. Colclough, C. Bellanné-Chantelot, C. Saint-Martin, S. Flanagan, S. Ellard   +4 more
semanticscholar   +1 more source

Variant Hepatocyte Nuclear Factor 1 expression in the mouse genital tract

Mechanisms of Development, 2001
Variant Hepatocyte Nuclear Factor 1 (vHNF1/HNF1beta) is a homeodomain-containing transcription factor first expressed in the primitive endoderm and its derivatives, the visceral and parietal endoderm. It is subsequently expressed in epithelial cells of different organs, including the primitive gut and derivatives (liver, pancreas, lung), the kidney ...
Silvia Cereghini, Michael Reber
openaire   +3 more sources

Hepatocyte Nuclear Factor-1α Gene Mutations and Diabetes in Norway [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene cause maturity-onset diabetes of the young (MODY), type 3. To estimate the prevalence of MODY3 in Norwegian diabetic pedigrees, we screened a total of 130 families for HNF-1 alpha mutations; 42 families with clinical MODY, 75 with suspected MODY, and 13 pedigrees with multiplex type 1 ...
Pål R. Njølstad, Pål R. Njølstad, Anders Molven, Per Medbøe Thorsby, Jørn V. Sagen, Lise Bjørkhaug, Oddmund Søvik   +6 more
openaire   +3 more sources

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29 [PDF]

, 2015
Background and aims: Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming.
Amicone, Laura, Battistelli, Cecilia, Brocker, Chad, Ciafrè, Silvia Anna, Cicchini, Carla, Cozzolino, ANGELA MARIA, DE NONNO, Valeria, DE SANTIS PUZZONIA, Marco, Gonzalez, Frank J., Tripodi, Marco   +9 more
core   +1 more source

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi   +11 more
doaj   +1 more source

Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

Frontiers in Pharmacology, 2018
Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed
Jingxin Mao, Man Yi, Rui Wang, Yuanshe Huang, Min Chen   +4 more
doaj   +1 more source