Results 201 to 210 of about 233,279 (266)

The High‐Sensitivity C‐Reactive Protein−Albumin−Lymphocyte Index Is a Prognostic Marker for All‐Cause and Cardiovascular Mortality in Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Inflammation and immune dysfunction may worsen the prognosis of patients with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess whether the high‐sensitivity C‐reactive protein–albumin–lymphocyte index (hsCALLYI) could be used to predict the prognosis of STEMI patients who received emergency ...
Xinuo Ma, Wei Zhang, Ningli Zhang, Qinghua Zhong, Tao Shi, Sirui Yang, Fazhi Yang, Yujuan Peng, Lixing Chen   +8 more
wiley   +1 more source

Loss of hepatocyte PI3Kα reduces hepatocellular carcinoma and hepatocyte proliferation in association with altered lipid metabolism. [PDF]

JHEP Rep
Becattini B, Sardi C, Edelbroek B, Chand Gupta A, Parris T, Helou K, Solinas G.   +6 more
europepmc   +1 more source

Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Chemistry – A European Journal, EarlyView.
ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo, Anne M. Noronha, Christopher J. Wilds   +2 more
wiley   +1 more source

Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics. [PDF]

Signal Transduct Target Ther
Tang X, Shi Y, Pan J, Zhao Y, Huang M, Su H, Zhou W, Luo X, Luo X, Zhang J, Zhao J, Jia J, Li J, Zhong B, Tang L, Chen Z, Ouyang Y, Dang Z, French SW, Huang Y, Pan X, Liu H.   +21 more
europepmc   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Antioxidant Therapy Reverses Hepatotoxicity Induced by Microcystin-LR in a Cellular Model of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

J Xenobiot
Lad A, Kindle J, Hegde P, Kleer GG, Kleinhenz AL, Birbeck JA, Westrick J, Peraino NJ, Hinds TD, Purandare N, Fribley AM, Haller ST, Kennedy DJ.   +12 more
europepmc   +1 more source

Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19. [PDF]

Cell Discov
Qu Y, Zhou J, Wang X, Dong S, Li J, Qiu L, Bian L, Yuan W, Xie Q, Qu J, Zhao Z, Wu X, Liang Q.   +12 more
europepmc   +1 more source

Protein quality control and antigen presentation in the development of hepatitis B-related hepatocellular carcinoma. [PDF]

Front Pharmacol
An L, Han Y, Sun X, Wang L, Guo L.
europepmc   +1 more source

GRP75 chaperone-driven mitochondria-ER membrane coupling promotes Ca²⁺-dependent ROS accumulation and ferroptosis during hypoxic stress. [PDF]

J Biol Chem
Yan H, Chen P, Zhang Y, He Q, Liu H, Liu Q, Song K, Yang S, Zhao L.   +8 more
europepmc   +1 more source

Genetic and pharmaceutical manipulation of H3K9 methyltransferase Suv39h1 promotes liver regeneration by unleashing HMGB2 transcription. [PDF]

Exp Mol Med
Lu Y, Zhou J, Miao X, Zeng S, Qin L, Xu Y, Wang S, Li Z.   +7 more
europepmc   +1 more source