Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]
, 2015 TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O +4 more
core +1 more source
Gut, 2018 Objective Alcoholic liver disease (ALD) is a leading cause of death among chronic liver diseases. However, its pathogenesis has not been completely established. MicroRNAs (miRNAs) are key contributors to liver diseases progression.
M. Heo +5 more
semanticscholar +1 more source
Cytomorphological Changes in the Hepate of the White Sea Coastal Cod (Gadus morhua maris-albi Derjugin, 1920) during Parasitic Invasions [PDF]
Учёные записки Казанского университета: Серия Естественные науки, 2015 The cod Gadus morhua maris-albi is one of the most heavily infested fish species in the White Sea. The fish liver (hepate) is a convenient model to study the pathogenesis in parasitosis.
Shakurova N.V., Kudryavtseva E.V.
doaj
The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes [PDF]
Animal Bioscience, 2023 Objective Cows that are nursing get around 80% of their glucose from liver gluconeogenesis. Propionate, a significant precursor of liver gluconeogenesis, can regulate the key genes involved in hepatic gluconeogenesis expression, but its precise effects ...
Rui Pang +7 more
doaj +1 more source
The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]
, 2011 Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E +20 more
core +6 more sources
Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression
Biomolecules, 2021 Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression.
Ja Hyun Koo, Chang Yeob Han
doaj +1 more source
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Nature, 2018 Hepatocytes are replenished gradually during homeostasis and robustly after liver injury1, 2. In adults, new hepatocytes originate from the existing hepatocyte pool3–8, but the cellular source of renewing hepatocytes remains unclear.
Shengda Lin +7 more
semanticscholar +1 more source
Hepatology, 2019 Liver regeneration after injury is normally mediated by proliferation of hepatocytes, although recent studies have suggested biliary epithelial cells (BECs) can differentiate into hepatocytes during severe liver injury when hepatocyte proliferation is ...
Jacquelyn O. Russell +8 more
semanticscholar +1 more source
Feedback Loops Shape Oxidative and Immune Interactions in Hepatic Ischemia–Reperfusion Injury
AntioxidantsReactive oxygen species (ROS) play a dual role as both essential signaling molecules and harmful mediators of damage. Imbalances in the redox state of the liver can overwhelm antioxidant defenses and promote mitochondrial dysfunction, oxidative damage ...
Kenneth J. Dery +3 more
doaj +1 more source
Effect of Thermal Stress on Caprine Hepatocyte’s Antioxidant Enzymes Activity and TGF β Secretion In Vitro [PDF]
Journal of Stress Physiology & Biochemistry, 2014 Liver is involved in several vital functions such as synthesis, secretion, storage and metabolism of plasma proteins and in detoxifying functions. In the present study, hepatocytes were obtained by disaggregation of caprine liver caudate lobe.
Phad Ashok Vyankati, Anand Laxmi
doaj