Results 31 to 40 of about 406,566 (292)

Irinotecan and Δ9-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers

Molecules, 2018
There is growing interest regarding the use of herbal preparations based on Cannabis sativa for medicinal purposes, despite the poorly understood interactions of their main constituent Δ9-tetrahydrocannabinol (THC) with conventional drugs ...
Ana Lucić Vrdoljak, Nino Fuchs, Anja Mikolić, Suzana Žunec, Irena Brčić Karačonji, Andreja Jurič, Ljerka Prester, Vedran Micek, Marijana Neuberg, Samir Čanović, Gordan Mršić, Nevenka Kopjar   +11 more
doaj   +1 more source

3D Hepatic Organoid-Based Advancements in LIVER Tissue Engineering

Bioengineering, 2021
Liver-associated diseases and tissue engineering approaches based on in vitro culture of functional Primary human hepatocytes (PHH) had been restricted by the rapid de-differentiation in 2D culture conditions which restricted their usability.
Amit Panwar, Prativa Das, Lay Poh Tan
doaj   +1 more source

Ursolic Acid Lactone Obtained from Eucalyptus tereticornis Increases Glucose Uptake and Reduces Inflammatory Activity and Intracellular Neutral Fat: An In Vitro Study

Molecules, 2021
Obesity has a strong relationship to insulin resistance and diabetes mellitus, a chronic metabolic disease that alters many physiological functions. Naturally derived drugs have aroused great interest in treating obesity, and triterpenoids are natural ...
Norman Balcazar, Laura I. Betancur, Diana L. Muñoz, Frankly J. Cabrera, Adriana Castaño, Luis F. Echeverri, Sergio Acin   +6 more
doaj   +1 more source

Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors [PDF]

, 1992
Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast,
Alessandro Azzarone, Antonio Francavilla, Braun, Carlo Scotti-Fogueni, Carr, Fausto, Francavilla, Francavilla, Goustin, Gruppuso, Guiseppe Carrieri, Houck, Kendrick Porter, Mazzaferro, Mead, Michalopoulos, Michalopoulos, Qia-Hua Zeng, Richman, Roberts, Short, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, Umberto Cillo   +28 more
core   +1 more source

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes

Biomolecules
About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-stage liver diseases are potentiated by alcohol.
Murali Ganesan, Anup S. Pathania, Grace Bybee, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna   +5 more
doaj   +1 more source

The sensitivity of cells with the various level of NAD(P)H:quinone oxidoreductase 1 to cytotoxic action of quinonimines and α-тоcopherol synthetic derivatives [PDF]

The Ukrainian Biochemical Journal, 2015
The effects of α-tocopherol with shortened to 6 carbon atoms side chain (α-Toc-C6), α-tocopherol succinate (α-TS) and quinonimine 2,6-dichlorophenolindophenol (DCPIP) on DT-diaphorase activity and viability of rat thymocytes, splenocytes and hepatocytes ...
G. V. Petrova, А. V. Parshykov
doaj   +1 more source

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]

, 1976
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard, Bollman, Bucher, Child, Eck, Felig, Felig, Field, Fisher, Fisher, Hahn, Holley, Izzo, Leffert, Loud, Madison, Mann, Marchioro, Marchioro, Marchioro, Meyer, Popper, Reaven, Rous, Rubin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Tchobroutsky, Warren, Wembren, Younger   +36 more
core   +1 more source

Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage liver fibrosis and cirrhosis are the leading causes of liver failure and liver-related death worldwide.
Jiaxin Chen, Linge Jian, Yangkun Guo, Chengwei Tang, Zhiyin Huang, Jinhang Gao   +5 more
doaj   +1 more source

Hepatitis C, Innate Immunity and Alcohol: Friends or Foes?

Biomolecules, 2015
Hepatitis C and alcohol are the most widespread causes of liver disease worldwide. Approximately 80% of patients with a history of hepatitis C and alcohol abuse develop chronic liver injury.
Natalia A. Osna, Murali Ganesan, Kusum K. Kharbanda   +2 more
doaj   +1 more source

Inhibitory Effect of IL-1β on HBV and HDV Replication and HBs Antigen-Dependent Modulation of Its Secretion by Macrophages

Viruses, 2021
Co-infection with the hepatitis B virus and hepatitis delta virus (HDV) leads to the most aggressive form of viral hepatitis. Using in vitro infection models, we confirmed that IL-1β, a crucial innate immune molecule for pathogen control, was very potent
Marion Delphin, Suzanne Faure-Dupuy, Nathalie Isorce, Michel Rivoire, Anna Salvetti, David Durantel, Julie Lucifora   +6 more
doaj   +1 more source