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Derivatization of soyasapogenol A and their hepatoprotective activities
Bioorganic & Medicinal Chemistry Letters, 1998Fifteen derivatives of soyasapogenol A (1), which is another aglycon moiety of soyasaponins from soybean together with soyasapogenol B (2), were prepared and their in vitro hepatoprotective effects were evaluated.
K, Sasaki +4 more
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Mechanisms of Tauroursodeoxycholate-Mediated Hepatoprotection
Digestive Diseases, 2017Ursodeoxycholate and its taurine conjugate tauroursodeoxycholate (TUDC) promote choleresis by triggering the insertion of transport proteins for bile acids into the canalicular and basolateral membranes of hepatocytes. In addition, TUDC exerts hepatoprotective and anti-apoptotic effects, can counteract the action of toxic bile acids and reduce ...
Dieter, Häussinger, Claus, Kordes
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Hepatoprotective activity of Gundelia tourenfortii
Journal of Ethnopharmacology, 2005Gundelia tourenfortii (L.), is used as an occasional food, and its extracts have been used for prevention and treatment of liver diseases in Iran. The effects of different concentrations of the hydroalcoholic extract of dried powdered footstalks of Gundelia tourenfortii were investigated on CCl4-induced hepatotoxicity using in vivo model in rats and ...
Akram, Jamshidzadeh +3 more
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Past and Present Scenario of Hepatoprotectants#
Current Medicinal Chemistry, 1999Abstract: The liver plays a significant role not only in metabolism and disposition of the chemicals to which it is exposed directly or indirectly but also plays a pivotal role in the metabolism of fats, carbohydrates, proteins and immunomodulations. The impairment of the liver generally results from viral or portozoal infections, excessive use of
V J, Ram, A, Goel
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Silymarin and hepatoprotection.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013To determine the hepatoprotective effect of silymarin with Chang cell cultures. Specifically, to investigate the antioxidant properties of silymarin and its protective function in reducing pro-apoptotic markers.Intracellular free radical levels were assessed with dichlorofluorescein (DCF) fluorescence after exposing cells to an oxidative stress of 400 ...
Frank J, Burczynski +5 more
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Hepatoprotective activity of Schouwia thebica webb
Bioorganic & Medicinal Chemistry Letters, 2006Oral administration of alcoholic extracts of Schouwia thebica Webb showed that extracts are safe for human use. The studied extracts are considered safe, since they failed to induce death of mice in doses up to 4000 mg/kg body weight. Hepatoprotective activity was studied for the total alcoholic extracts. The total extract was fractionated in turn with
Maitland, Derek J. +2 more
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Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2016
The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity.
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The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity.
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NEPHROPROTECTIVE AND HEPATOPROTECTIVE EFFECTS OF CURCUMINOIDS
2007Curcumin (U1) has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities. By comparison of the structure-activity relationship, tetrahydrocurcumin (THU1), one of the major metabolites, showed the highest antioxidative activity in both in vitro ...
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