Results 1 to 10 of about 160,647 (335)

Real-world evidence of ribociclib-induced hepatotoxicity in patients with breast cancer: a multi-center experience [PDF]

BMC Cancer
Background CDK4/6 inhibitors are primarily used to treat hormone-positive HER-2 negative (HR+/ HER2-) metastatic breast cancer. Although ribociclib is generally well-tolerated, there is limited real-world data on hepatotoxicity associated with its use ...
Onur Baş, Bediz Kurt İnci, İmdat Eroğlu, Safa Can Efil, Seher Kaya, Pınar Kubilay Tolunay, Taha Koray Şahin, Cengiz Karaçin, Ozan Yazıcı, Mehmet Ali Nahit Şendur, Berna Ömür Çakmak Öksüzoğlu, Sercan Aksoy   +11 more
doaj   +2 more sources

ABCB1 Polymorphism in HIV-Infected Individuals Taking Antiretroviral Drugs [PDF]

AIDS Research and Treatment
ABC transporter P-glycoprotein (P-gp) and its expression enhance elimination and reduce drug exposure. The elimination of non-nucleoside reverse-transcriptase inhibitor (NNRTIs) drugs is associated with ABCB1 gene.
HariOm Singh, Dharmesh Samani, Supriya D. Mahajan   +2 more
doaj   +2 more sources

Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications [PDF]

International Journal of Hepatology
Antitubercular (AT) drugs, particularly isoniazid (INH), rifampicin (RIF), pyrazinamide (PYZ), and ethambutol (EMB), are the cornerstone of tuberculosis (TB) treatment.
Debasree Bishnu, Suman Santra, Swagata Purkait, Amal Santra   +3 more
doaj   +2 more sources

Hepatotoxicity risk factors in HIV-infected MSM with HBV/HCV coinfections: A cohort study in Northwestern China. [PDF]

PLoS ONE
ObjectiveTo evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) initiating their first antiretroviral therapy (ART) in Northwestern ...
Xinyu Ma, Ruimin Bai, Zirong Zhu, Tongquan Wang, Xinrong Zhao, Yan Sun, Yan Zheng   +6 more
doaj   +2 more sources

Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine the effect of genetic polymorphism of N-acetyltransferase 2 (NAT2) and cytochrome ...
Nasir Pourmohamadi, Mihan Pour Abdollah Toutkaboni, Nasim Hayati Roodbari, Payam Tabarsi, Shadi Baniasad   +4 more
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
A Tostmann, Atikaimu Wubuli, B Roy, B Roy, C Benichou, Corinne Merle, D Yee, DL Zhu, DS Huang, DW Hein, H Devarbhavi, HG Xie, HJ Cho, HJ De Rosa, HR An, HR An, I Vieira, J Meyer D, JH Wang, Jiayi Gu, Jinfeng Ma, JJ Saukkonen, JN Hirschhorn, JN Pande, JR Mitchell, JR Mitchell, Lei Yang, LG Possuelo, Long Ma, M Dossing, M Guo, M Guo, M Ingelman-Sundberg, M Ohno, M Runge-Morris, Mark Patrick Nicol, Mingqin Cao, N Vuilleumier, Paul Milligan, PD Bose, PD Roy, Qian Wang, Qian Wang, R Shakya, RC Strange, RL Teixeira, S Chatterjee, S Huang Y, S Russmann, S Sunahara, S Yamada, SH Kim, SH Kim, SK Sharma, SW Lee, SW Tang, T Mohri, T Sotsuka, T Wang, T Wang, T Yamamoto, V Leiro, Wei Liu, Weidong Wu, WJ Burman, WM Lee, WW Yew, Xia Zhu, Xiumei Xin, Xuemei Yao, XZ Lv, Y Chen, Yang Xiang, Ying Mao, YM Wu, Yongguang Li, YS Huang, YS Huang, YS Huang, YS Huang   +79 more
core   +11 more sources

Machine Learning Approaches to Predict Hepatotoxicity Risk in Patients Receiving Nilotinib

Molecules, 2021
Background: Although nilotinib hepatotoxicity can cause severe clinical conditions and may alter treatment plans, risk factors affecting nilotinib-induced hepatotoxicity have not been investigated.
Jung-Sun Kim, Ji-Min Han, Yoon-Sook Cho, Kyung-Hee Choi, Hye-Sun Gwak   +4 more
doaj   +1 more source

The molecular pathogenesis of triptolide-induced hepatotoxicity

Frontiers in Pharmacology, 2022
Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity ...
Yeqing Hu, Yeqing Hu, Yeqing Hu, Qiguo Wu, Yulin Wang, Yulin Wang, Yulin Wang, Haibo Zhang, Haibo Zhang, Haibo Zhang, Xueying Liu, Xueying Liu, Xueying Liu, Hua Zhou, Hua Zhou, Hua Zhou, Tao Yang, Tao Yang, Tao Yang, Tao Yang   +19 more
doaj   +1 more source

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

Toxicology Reports, 2020
As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed.
Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. Seeff, Andrew Stolz, Jawad Ahmad, Christopher Koh, Jose Serrano, Tieraona Low Dog, Richard Ko   +25 more
doaj   +1 more source

Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. [PDF]

PLoS ONE, 2016
Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living
Carolline Araújo-Mariz, Edmundo Pessoa Lopes, Bartolomeu Acioli-Santos, Magda Maruza, Ulisses Ramos Montarroyos, Ricardo Arraes de Alencar Ximenes, Heloísa Ramos Lacerda, Demócrito de Barros Miranda-Filho, Maria de Fátima P Militão de Albuquerque   +8 more
doaj   +1 more source