Real-world evidence of ribociclib-induced hepatotoxicity in patients with breast cancer: a multi-center experience [PDF]
BMC CancerBackground CDK4/6 inhibitors are primarily used to treat hormone-positive HER-2 negative (HR+/ HER2-) metastatic breast cancer. Although ribociclib is generally well-tolerated, there is limited real-world data on hepatotoxicity associated with its use ...
Onur Baş +11 more
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ABCB1 Polymorphism in HIV-Infected Individuals Taking Antiretroviral Drugs [PDF]
AIDS Research and TreatmentABC transporter P-glycoprotein (P-gp) and its expression enhance elimination and reduce drug exposure. The elimination of non-nucleoside reverse-transcriptase inhibitor (NNRTIs) drugs is associated with ABCB1 gene.
HariOm Singh +2 more
doaj +2 more sources
Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications [PDF]
International Journal of HepatologyAntitubercular (AT) drugs, particularly isoniazid (INH), rifampicin (RIF), pyrazinamide (PYZ), and ethambutol (EMB), are the cornerstone of tuberculosis (TB) treatment.
Debasree Bishnu +3 more
doaj +2 more sources
Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine the effect of genetic polymorphism of N-acetyltransferase 2 (NAT2) and cytochrome ...
Nasir Pourmohamadi +4 more
doaj +1 more source
Machine Learning Approaches to Predict Hepatotoxicity Risk in Patients Receiving Nilotinib
Molecules, 2021 Background: Although nilotinib hepatotoxicity can cause severe clinical conditions and may alter treatment plans, risk factors affecting nilotinib-induced hepatotoxicity have not been investigated.
Jung-Sun Kim +4 more
doaj +1 more source
The molecular pathogenesis of triptolide-induced hepatotoxicity
Frontiers in Pharmacology, 2022 Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity ...
Yeqing Hu +19 more
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United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts
Toxicology Reports, 2020 As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed.
Hellen A. Oketch-Rabah +25 more
doaj +1 more source
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. [PDF]
PLoS ONE, 2016 Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living
Carolline Araújo-Mariz +8 more
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Case Reports in Oncology, 2021 Alectinib is a key drug for treating anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Alectinib-induced hepatotoxicity is less common than that through other ALK inhibitors, such as crizotinib or ceritinib.
Go Makimoto +4 more
doaj +1 more source
Navigating liver cancer with mouse models: a comprehensive overview of HCC experimental systems [PDF]
Journal of Liver CancerHepatocellular carcinoma (HCC) is the most prevalent primary hepatic malignancy and is globally the third leading cause of cancerrelated deaths. Despite significant advancements in diagnostic techniques and therapeutic interventions, HCC prognosis ...
Ga-Young Kim +4 more
doaj +1 more source