Real-world pharmacovigilance assessment of hepatotoxicity risk with HER2-Targeted drugs using FAERS database analysis [PDF]
Scientific ReportsHuman epidermal growth factor receptor 2 (HER2)-targeted therapies, including monoclonal antibodies (mAbs), small-molecule tyrosine kinase inhibitors (TKIs), and antibody-drug conjugates (ADCs), have significantly improved clinical outcomes in HER2 ...
Junli Dong +3 more
doaj +2 more sources
Hepatotoxicity risk factors in HIV-infected MSM with HBV/HCV coinfections: A cohort study in Northwestern China. [PDF]
PLoS ONEObjectiveTo evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) initiating their first antiretroviral therapy (ART) in Northwestern ...
Xinyu Ma +6 more
doaj +2 more sources
Anesthesia & Analgesia, 1986 We evaluated 88 cases of hepatic injury that followed, and were attributed to, enflurane anesthesia. In 30 of the cases, data were insufficient to assess the role of enflurane vs other variables as causal factors. In 43 ("unlikely") patients, factors known to produce hepatic injury were clearly present; in the remaining 15 ("possible"), such factors ...
Edmond I. Eger +4 more
openalex +5 more sources
Real-world data of Azvudine-induced hepatotoxicity among hospitalized COVID-19 patients in China: a retrospective case-control study [PDF]
Frontiers in PharmacologyBackgroundThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global health crisis. Although several antiviral drugs have been used to mitigate the severity and mortality of COVID-19, the safety profile remained a critical concern. Azvudine,
Yuanguo Xiong +8 more
doaj +2 more sources
Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine the effect of genetic polymorphism of N-acetyltransferase 2 (NAT2) and cytochrome ...
Nasir Pourmohamadi +4 more
doaj +1 more source
Coumarin-Induced Hepatotoxicity: A Narrative Review
Molecules, 2022 Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in the
Michele Pitaro +5 more
semanticscholar +1 more source
Machine Learning Approaches to Predict Hepatotoxicity Risk in Patients Receiving Nilotinib
Molecules, 2021 Background: Although nilotinib hepatotoxicity can cause severe clinical conditions and may alter treatment plans, risk factors affecting nilotinib-induced hepatotoxicity have not been investigated.
Jung-Sun Kim +4 more
doaj +1 more source
The molecular pathogenesis of triptolide-induced hepatotoxicity
Frontiers in Pharmacology, 2022 Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity ...
Yeqing Hu +19 more
doaj +1 more source
Antidepressants- and antipsychotics-induced hepatotoxicity
Archives of Toxicology, 2021 Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common ...
N. Todorović Vukotić +4 more
semanticscholar +1 more source
Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug
Drug Metabolism And Disposition, 2021 Pyrazinamide (PZA) is an important component of a standard combination therapy against tuberculosis. However, PZA is hepatotoxic, and the underlying mechanisms are poorly understood.
Zahir Hussain, Junjie Zhu, Xiaochao Ma
semanticscholar +1 more source