Results 21 to 30 of about 137,616 (341)

Alleviation of cisplatin‐induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase‐3 activity

Pharmacology Research & Perspectives, 2021
Cisplatin (CP), as an effective alkylating agent, is widely used in cancer treatment, while hepatotoxicity is one of its side effects. Gliclazide (GLZ), as an oral hypoglycemic drug, has antioxidant and anti‐inflammatory properties.
F. Taghizadeh, S. Hosseinimehr, M. Zargari, A. Karimpour Malekshah, Mansoureh Mirzaei, Fereshteh Beigom Talebpour Amiri   +5 more
semanticscholar   +1 more source

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

Toxicology Reports, 2020
As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed.
Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. Seeff, Andrew Stolz, Jawad Ahmad, Christopher Koh, Jose Serrano, Tieraona Low Dog, Richard Ko   +25 more
doaj   +1 more source

Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. [PDF]

PLoS ONE, 2016
Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living
Carolline Araújo-Mariz, Edmundo Pessoa Lopes, Bartolomeu Acioli-Santos, Magda Maruza, Ulisses Ramos Montarroyos, Ricardo Arraes de Alencar Ximenes, Heloísa Ramos Lacerda, Demócrito de Barros Miranda-Filho, Maria de Fátima P Militão de Albuquerque   +8 more
doaj   +1 more source

Increased hepatotoxicity among HIV-infected adults co-infected with Schistosoma mansoni in Tanzania: A cross-sectional study. [PDF]

PLoS Neglected Tropical Diseases, 2017
Little is known about hepatotoxicity in patients with schistosome and HIV co-infections. Several studies have reported increased liver enzymes and bilirubin levels associated with schistosome infection.
Amon I Marti, Soledad Colombe, Peter J Masikini, Samuel E Kalluvya, Luke R Smart, Bahati M Wajanga, Hyasinta Jaka, Robert N Peck, Jennifer A Downs   +8 more
doaj   +1 more source

Successful Treatment with Lorlatinib after the Development of Alectinib-Induced Liver Damage in ALK-Positive Non-Small-Cell Lung Cancer: A Case Report

Case Reports in Oncology, 2021
Alectinib is a key drug for treating anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Alectinib-induced hepatotoxicity is less common than that through other ALK inhibitors, such as crizotinib or ceritinib.
Go Makimoto, Keita Kawakado, Masamoto Nakanishi, Tomoki Tamura, Shoichi Kuyama   +4 more
doaj   +1 more source

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

Journal of Clinical and Translational Hepatology, 2016
Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within ...
Eric D. Yoon, A. Babar, M. Choudhary, M. Kutner, N. Pyrsopoulos   +4 more
semanticscholar   +1 more source

Assessment of Risk Factors of Hepatotoxicity among Tuberculosis Patients

Pharmacology and Clinical Pharmacy Research, 2018
Tuberculosis is a devastating disease caused by Mycobacterium tuberculosis. If left untreated or not properly treated, it could lead to progressive tissue damage and even death. Short-term chemotherapy containing isoniazid, rifampicin.
Muhammad F. Wardhana, Tiana Milanda, Sri A. Sumiwi   +2 more
doaj   +1 more source

Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari, Hossein Babaei, Leila Roshangar, Mohammad Ali Eghbal   +3 more
doaj   +1 more source

Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013-2015

Indonesian Journal of Rheumatology, 2018
Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients.
Rahma Anindya Prathitasari, Harry Isbagio   +1 more
doaj   +1 more source

Evaluation of factors affecting epidermal growth factor receptor tyrosine kinase inhibitor-induced hepatotoxicity in Japanese patients with non-small cell lung cancer: a two-center retrospective study

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Gefitinib and erlotinib, are epidermal growth factor receptor tyrosine kinase inhibitors, and are currently recommended for non-small cell lung cancer stage IV in the elderly and in patients with decreased performance status in the Japanese ...
Hirofumi Nagai, Tsutomu Shimada, Yoshimitsu Takahashi, Mikako Nishikawa, Hiroyuki Tozuka, Yasuto Yamamoto, Osamu Niwa, Yutaka Takahara, Arimi Fujita, Katsuhiko Nagase, Kazuo Kasahara, Seiji Yano, Yoshimichi Sai   +12 more
doaj   +1 more source