Results 41 to 50 of about 137,616 (341)

Incidence of Hepatotoxicity and Factors Associated During Highly Active Antiretroviral Therapy in People Living with HIV in Ethiopia: A Prospective Cohort Study

HIV/AIDS: Research and Palliative Care, 2021
Gebremedhin Gebremicael, Habteyes Hailu Tola, Atsbeha Gebreegziaxier, Desta Kassa HIV and TB Diseases Research Directorate, Ethiopian Public Health Institute (EPHI), Addis Ababa, EthiopiaCorrespondence: Gebremedhin GebremicaelEthiopian Public Health ...
Gebremicael G, Tola HH, Gebreegziaxier A, Kassa D   +3 more
doaj  

Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study

BMC Cancer, 2018
Background Erlotinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Severe hepatotoxicity was observed in 4% to 31% of patients receiving erlotinib treatment prompting delay or termination of treatment. Only
Min Kyoung Kim, Jeong Yee, Yoon Sook Cho, Hong Won Jang, Ji Min Han, Hye Sun Gwak   +5 more
doaj   +1 more source

Hepatotoxicity of Chemotherapy

The Oncologist, 2001
Abstract After assessment of tumor histology, the next important factor to consider in the selection of a chemotherapy regime is organ function. Patients who are to receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate, and which drug doses should be modified.
Michael C. Perry, Paul D. King
openaire   +3 more sources

Nevirapine-associated early hepatotoxicity: incidence, risk factors, and associated mortality in a primary care ART programme in South Africa. [PDF]

PLoS ONE, 2010
The majority of antiretroviral treatment programmes in sub-Saharan Africa are scaling up antiretroviral treatment using a fixed dose first-line antiretroviral regimen containing stavudine, lamivudine, and nevirapine.
Kathryn M Chu, Andrew M Boulle, Nathan Ford, Eric Goemaere, Valerie Asselman, Gilles Van Cutsem   +5 more
doaj   +1 more source

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

Pharmaceuticals, 2022
Toosendanin (TSN) is a triterpenoid from the fruit or bark of Melia toosendan Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application.
Li Luo, Yonghong Liang, Yuanyuan Fu, Zhiyuan Liang, Jinfen Zheng, Jie Lan, Feihai Shen, Zhiying Huang   +7 more
doaj   +1 more source

Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles

Particle and Fibre Toxicology, 2019
Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed to the environment and the public.
Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou, G. Jia   +4 more
semanticscholar   +1 more source

Prevalence of ABCC3‐1767G/A polymorphism among patients with antiretroviral‐associated hepatotoxicity

Molecular Genetics & Genomic Medicine, 2020
Background Plasma concentrations of antiretrovirals (ARVs) regimens have considerably varied in individuals of human immunodeficiency virus (HIV) because of variations in the expression of drug‐metabolizing and transporter genes.
HariOm Singh, Sonam Lata, Ranjana Choudhari, Tapan N. Dhole   +3 more
doaj   +1 more source

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Toxicological Sciences, 2018
High failure rates of drug candidates in the clinics, restricted-use warnings as well as withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical industry and drug-induced liver injury (DILI) constitutes one of the ...
Sabine U. Vorrink, Yitian Zhou, M. Ingelman-Sundberg, V. M. Lauschke   +3 more
semanticscholar   +1 more source

Papaverine and hepatotoxicity [PDF]

Postgraduate Medical Journal, 1980
Abstract Six of 14 patients receiving a sustained release papaverine preparation developed abnormal liver function tests. One patient had jaundice and another abnormal liver histology on a biopsy specimen. This is only the third report of impaired liver function following the administration of papaverine--a drug which has been used in ...
M. S. Pathy, A. J. Reynolds
openaire   +3 more sources

Incidence, mortality, and risk factors of immunotherapy-associated hepatotoxicity: A nationwide hospitalization analysis

Liver Research, 2021
Background and aims: Anti-neoplastic immunotherapy has revolutionized cancer management; however, its safety profile with respect to liver-related injury remains largely unexplored.
Simcha Weissman, Saad Saleem, Sachit Sharma, Menashe Krupka, Faisal Inayat, Muhammad Aziz, James H. Tabibian   +6 more
doaj   +1 more source