Results 71 to 80 of about 137,616 (341)

Exploring the Mechanism of Hepatotoxicity Induced by Dictamnus dasycarpus Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology

open access: yesMolecules, 2023
The root bark of Dictamnus dasycarpus Turcz is a traditional Chinese medicine, Dictamni Cortex (DC), which is mainly used in the clinical treatment of skin inflammation, eczema, rubella, rheumatism, and gynecological inflammation. Unexpectedly, there are
Peng Gao   +8 more
doaj   +1 more source

Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications

open access: yesAdvanced Materials, EarlyView.
Vasculature is indispensable for tissue viability in regenerative medicine. The sacrificial biofabrication enables precise fabrication of vascular channels by using temporary templates that are subsequently removed. This review defines the concept and delves into sacrificial materials, surrounding materials, fabrication technologies, and biomedical ...
Jiezhong Shi   +7 more
wiley   +1 more source

Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysisResearch in context

open access: yesEBioMedicine
Summary: Background: Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations ...
Sophie M. Ernst   +13 more
doaj   +1 more source

Liver injury is most commonly due to hepatic metastases rather than drug hepatotoxicity during pembrolizumab immunotherapy

open access: yesAlimentary Pharmacology and Therapeutics, 2019
Pembrolizumab immunotherapy has been associated with hepatotoxicity in 1%‐10% of oncology patients treated in clinical trials.
I. Tsung   +6 more
semanticscholar   +1 more source

Fabrication of Multimodal Anion Exchange Membrane for Chromatographic Purification of Full Adeno‐Associated Viral Capsids

open access: yesAdvanced Materials Interfaces, EarlyView.
A novel multi‐modal anion exchange membrane (MMAEX) is successfully fabricated for separating empty and full AAV2 capsids. The functionalized membrane has an average pore size of 0.5 µm and exhibits both charge and hydrophobic functionality. A full capsid recovery of 72.9% at 85.3% purity with gradient elution, or 70.3% recovery at 92.2% purity with ...
Xiaolei Hao   +2 more
wiley   +1 more source

Farmakogenomik Hepatotoksisitas Obat Anti Tuberkulosis [Hepatotoxicity Pharmacogenomic of Anti Tuberculosis Drugs]

open access: yesJurnal Respirasi, 2015
Anti-TB drugs (ATD) associated with hepatotoxicity is a serious medical problem in the world, especially for patients with TB. The production and expenditures toxic drug metabolites depends on the activity of some enzymes, such as N-acetyl transferase 2 (
Andri Dwi Wahyudi, Soedarsono Soedarsono
doaj   +1 more source

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

open access: yesBMC Research Notes, 2020
Objectives Anti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus ...
Abebe Zeleke   +2 more
doaj   +1 more source

Acute and subacute hepatotoxicity of genipin in mice and its potential mechanism

open access: yesHeliyon, 2023
Gardenia, as a medicinal and edible herb, has the pharmacological activity of protecting the liver and cholagogue, but the hepatotoxicity induced by the chemical component genipin (GP) limits its application.
Shuaikang Wang   +8 more
doaj   +1 more source

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

open access: yesFrontiers in Pharmacology, 2018
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underlying
A. Moles   +4 more
semanticscholar   +1 more source

Advanced Materials in Responsible Electronics: Innovations for Sustainability, Health, and Circularity

open access: yesAdvanced Materials Technologies, EarlyView.
Contemporary electronic devices produce significant waste, harming ecosystems. Innovation in design, consumption, materials, and end‐of‐life management is crucial. This review explores advanced materials for sustainable and responsible electronics, highlighting their potential to reduce environmental and health hazards while improving device ...
Rawan Omar   +7 more
wiley   +1 more source

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