Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury [PDF]
Cell Death Discovery, 2023 Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by hepatotoxins.
Katherine Byrnes +9 more
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Hepatotoxin microcystin-LR extraction optimization [PDF]
Journal of the Brazilian Chemical Society, 2009 Several cyanobacterial genera produce toxic secondary metabolites, the most well-known of which are the hepatotoxic microcystins (MCYSTs). Microcystin analyses in drinking water are a requirement of the Health Ministry (Regulation 518/2004) in Brazil ...
ALVES, Ivânio R. +5 more
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Acetaminophen-cysteine adducts during therapeutic dosing and following overdose [PDF]
BMC Gastroenterology, 2011 Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S +6 more
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Purification and Mechanism of Microcystinase MlrC for Catalyzing Linearized Cyanobacterial Hepatotoxins Using Sphingopyxis sp. USTB-05 [PDF]
Toxins, 2022 Cyanobacterial hepatotoxins, including microcystins (MCs) and nodularins (NODs), are widely produced, distributed and extremely hazardous to human beings and the environment.
Qianwen Zou +9 more
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Prostanoids in Liver Repair and Regeneration: Biosynthesis, Receptors, and Intercellular CommunicationSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyProstanoids typically refer to prostaglandins, prostacyclin, and thromboxane, and are a series of bioactive lipid mediators primarily derived from arachidonic acid. Prostanoids play pivotal roles in various physiological processes, including liver repair
Xinzhi Li +5 more
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Transcriptional changes impact hepatic proteome in autophagy‐impaired liver [PDF]
FEBS Open BioHepatic proteomes are intricately controlled through biosynthesis, extracellular secretion, and intrahepatic degradation. Autophagy governs lysosome‐mediated intrahepatic degradation and the hepatic proteome.
Kamal Baral +13 more
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The role of 2ʹ–5ʹ-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice [PDF]
Scientific ReportsFollowing an injury, the liver embarks on a process that drives the accumulation and reformation of the extracellular matrix, leading to hepatic fibrosis. Type I interferons (IFNs), including IFN-α and IFN-β, play a crucial role in averting chronic liver
Mwense Leya +7 more
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Alterations in Lipid Metabolism and Hepatopancreatic Lipidomics Induced by Microcystin-LR Exposure in Common Carp (Cyprinus carpio) [PDF]
AnimalsMicrocystin-LR (MC-LR) is a hepatotoxin produced by toxic cyanobacteria such as Microcystis aeruginosa and it poses significant risks to aquatic organisms and human health.
Haoyang Zhao +4 more
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Biosynthesis of Strontium Nanoparticles Using Mimosa pudica and its Antioxidant Effect
Journal of Pharmacy and Bioallied SciencesA new area of nanotechnology, “green synthesis” studies nanomaterials utilizing natural biomaterials like plants, flowers, and microbesGreen nanoparticle synthesis offers various benefits, such as cost efficiency, pollution reduction, and environmental ...
Vallinayaki KN +2 more
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A HepG2 Cell-Based Biosensor That Uses Stainless Steel Electrodes for Hepatotoxin Detection
Biosensors, 2022 Humans are frequently exposed to environmental hepatotoxins, which can lead to liver failure. Biosensors may be the best candidate for the detection of hepatotoxins because of their high sensitivity and specificity, convenience, time-saving, low cost ...
Martin Rozman +6 more
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