Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. [PDF]
PLoS ONE, 2008 Overexpression of the human c-MYC (MYC) oncogene is one of the most frequently implicated events in the pathogenesis of hepatocellular carcinoma (HCC).
Shelly Beer +5 more
doaj +3 more sources
Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. [PDF]
PLoS Neglected Tropical Diseases, 2011 Eggs deposited in the liver of the mammalian host by the blood fluke parasite, Schistosoma mansoni, normally drive a T-helper-2 (Th2)-mediated granulomatous response in immune-competent mice.
Maha-Hamadien Abdulla +3 more
doaj +3 more sources
1,1-Dichloroethylene: An Apoptotic Hepatotoxin? [PDF]
Environmental Health Perspectives, 1984 Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial matrices.
E S, Reynolds +3 more
openaire +5 more sources
Climate change and regulation of hepatotoxin production in Cyanobacteria [PDF]
FEMS Microbiology Ecology, 2014 Harmful, bloom-forming cyanobacteria (CyanoHABs) are occurring with increasing regularity in freshwater and marine ecosystems. The most commonly occurring cyanobacterial toxins are the hepatotoxic microcystin and nodularin. These cyclic hepta- and pentapeptides are synthesised nonribosomally by the gene products of the toxin gene clusters mcy and nda ...
Michelle M, Gehringer, Nicola, Wannicke
openaire +4 more sources
Molecular detection of hepatotoxic cyanobacteria in inland water bodies of the Marmara Region, Turkey [PDF]
Advances in Oceanography and Limnology, 2017 Blooms of cyanobacteria are an increasingly frequent phenomenon in freshwater ecosystems worldwide as a result of eutrophication. Many species can produce hepatotoxins that cause severe health hazards to humans.
Latife Köker +3 more
doaj +3 more sources
Experimental models used for the study of antihepatotoxic agents [PDF]
Journal of Acute Disease, 2012 Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. These systems measure the ability of the test drug to prevent or cure liver toxicity (induced by various hepatotoxins) in experimental ...
Feroz Ahmad, Nahida Tabassum
doaj +2 more sources
Ammonia as a neuro- and hepatotoxin: clinical aspects [PDF]
Медицинский совет, 2015 Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as
A. O. Bueverov
doaj +2 more sources
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. [PDF]
Toxicol SciAcetaminophen is commonly used as a reference hepatotoxin to demonstrate that in vitro human liver platforms can emulate features of clinical drug-induced liver injury.
Livoti LA +7 more
europepmc +2 more sources
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury [PDF]
, 2021 Acetaminophen (N-acetyl-p-aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has been ...
Tan, Jessie +31 more
core +2 more sources
Stereoselective Total Synthesis of the Cyanobacterial Hepatotoxin 7-Epicylindrospermopsin: Revision of the Stereochemistry of Cylindrospermopsin [PDF]
, 2016 Stereoselective Total Synthesis of the Cyanobacterial Hepatotoxin 7-Epicylindrospermopsin: Revision of the Stereochemistry of ...
Grier A. Wallace (2365516) +4 more
core +1 more source