Results 11 to 20 of about 4,105 (286)
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. [PDF]
PLoS ONE, 2008 Overexpression of the human c-MYC (MYC) oncogene is one of the most frequently implicated events in the pathogenesis of hepatocellular carcinoma (HCC).
Shelly Beer +5 more
doaj +2 more sources
Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. [PDF]
PLoS Neglected Tropical Diseases, 2011 Eggs deposited in the liver of the mammalian host by the blood fluke parasite, Schistosoma mansoni, normally drive a T-helper-2 (Th2)-mediated granulomatous response in immune-competent mice.
Maha-Hamadien Abdulla +3 more
doaj +2 more sources
Digestive Diseases, 2008 Although essential for life, iron in excessive amounts may be toxic. The liver is particularly subject to the toxic effects of iron, since it is the major site of iron storage. Several inherited and acquired human disorders may result in hepatic iron overload, the most common of which are genetic hemochromatosis (GH) and transfusional iron overload. GH
STAL, P
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1,1-Dichloroethylene: An Apoptotic Hepatotoxin? [PDF]
Environmental Health Perspectives, 1984 Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial matrices.
E S, Reynolds +3 more
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Climate change and regulation of hepatotoxin production in Cyanobacteria [PDF]
FEMS Microbiology Ecology, 2014 Harmful, bloom-forming cyanobacteria (CyanoHABs) are occurring with increasing regularity in freshwater and marine ecosystems. The most commonly occurring cyanobacterial toxins are the hepatotoxic microcystin and nodularin. These cyclic hepta- and pentapeptides are synthesised nonribosomally by the gene products of the toxin gene clusters mcy and nda ...
Michelle M, Gehringer, Nicola, Wannicke
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Molecular detection of hepatotoxic cyanobacteria in inland water bodies of the Marmara Region, Turkey [PDF]
Advances in Oceanography and Limnology, 2017 Blooms of cyanobacteria are an increasingly frequent phenomenon in freshwater ecosystems worldwide as a result of eutrophication. Many species can produce hepatotoxins that cause severe health hazards to humans.
Latife Köker +3 more
doaj +2 more sources
Experimental models used for the study of antihepatotoxic agents [PDF]
Journal of Acute Disease, 2012 Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. These systems measure the ability of the test drug to prevent or cure liver toxicity (induced by various hepatotoxins) in experimental ...
Feroz Ahmad, Nahida Tabassum
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Ammonia as a neuro- and hepatotoxin: clinical aspects
Медицинский совет, 2015 Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as
A. O. Bueverov
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Papaverine Revisited as a Hepatotoxin
New England Journal of Medicine, 1969 The proliferation of therapeutic agents during the past quarter-century has been accompanied by an increased frequency of drug-induced hepatic disease.1 , 2 Usually, the ability of an agent to produce hepatic injury is recognized within a few years of its introduction into clinical use.
Hyman J. Zimmerman
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Degradation of the cyanobacterial hepatotoxin microcystin by aquatic bacteria
Natural Toxins, 1994 AbstractBacterial degradation of the cyanobacterial cyclic peptide hepatotoxin microcystin was confirmed in natural waters and by isolated laboratory strains. Degradation of 1 mg L−1 microcystin LR typically began 2‐8 days after addition to surface water samples. At concentrations greater than 1 mg L1 there was an initial slow removal of microcystin LR,
Jones, Gary J. +3 more
openaire +6 more sources