Results 11 to 20 of about 4,163 (290)

Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. [PDF]

PLoS ONE, 2008
Overexpression of the human c-MYC (MYC) oncogene is one of the most frequently implicated events in the pathogenesis of hepatocellular carcinoma (HCC).
Shelly Beer, Kimberly Komatsubara, David I Bellovin, Masashi Kurobe, Karl Sylvester, Dean W Felsher   +5 more
doaj   +2 more sources

Molecular detection of hepatotoxic cyanobacteria in inland water bodies of the Marmara Region, Turkey [PDF]

Advances in Oceanography and Limnology, 2017
Blooms of cyanobacteria are an increasingly frequent phenomenon in freshwater ecosystems worldwide as a result of eutrophication. Many species can produce hepatotoxins that cause severe health hazards to humans.
Latife Köker, Reyhan Akçaalan, Meriç Albay, Brett A. Neilan   +3 more
doaj   +2 more sources

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. [PDF]

PLoS Neglected Tropical Diseases, 2011
Eggs deposited in the liver of the mammalian host by the blood fluke parasite, Schistosoma mansoni, normally drive a T-helper-2 (Th2)-mediated granulomatous response in immune-competent mice.
Maha-Hamadien Abdulla, Kee-Chong Lim, James H McKerrow, Conor R Caffrey   +3 more
doaj   +2 more sources

Climate change and regulation of hepatotoxin production in Cyanobacteria [PDF]

FEMS Microbiology Ecology, 2014
Harmful, bloom-forming cyanobacteria (CyanoHABs) are occurring with increasing regularity in freshwater and marine ecosystems. The most commonly occurring cyanobacterial toxins are the hepatotoxic microcystin and nodularin. These cyclic hepta- and pentapeptides are synthesised nonribosomally by the gene products of the toxin gene clusters mcy and nda ...
Michelle M, Gehringer, Nicola, Wannicke
openaire   +3 more sources

Experimental models used for the study of antihepatotoxic agents

Journal of Acute Disease, 2012
Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. These systems measure the ability of the test drug to prevent or cure liver toxicity (induced by various hepatotoxins) in experimental ...
Feroz Ahmad, Nahida Tabassum
doaj   +2 more sources

Anti-oxidant protective effects of Cassia alata in rats exposed to carbon tetrachloride

Journal of Applied Sciences and Environmental Management, 2006
The protective activity of Cassia alata against carbon tetrachloride (CCl4) – induced hepatotoxicity in rats was assessed. Crude extracts of petals of the plant in 0.5% ethanol were administered by intubation for 14 days prior to injection of 0.5ml Kg-1 ...
MO Wegwu, EO Ayalogu, OJ Sule
doaj   +2 more sources

Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. [PDF]

Toxicol Sci
Acetaminophen is commonly used as a reference hepatotoxin to demonstrate that in vitro human liver platforms can emulate features of clinical drug-induced liver injury.
Livoti LA, Sison-Young R, Reddyhoff D, Fisher CP, Gardner I, Diaz-Nieto R, Goldring CE, Copple IM.   +7 more
europepmc   +2 more sources

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury [PDF]

, 2021
Acetaminophen (N-acetyl-p-aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has been ...
Tan, Jessie, Viswanathan, Sivakumar, Schafer, Sebastian, Wang, Mao, Holgate, Robert, Lim, Sze Yun, Widjaja, Anissa A, Yen, Paul M., Widjaja, Anissa A., Ng, Benjamin K, Lim, Wei Wen, Ng, Benjamin, Felkin, Leanne E, Drum, Chester L, Chothani, Sonia P, Shekeran, Shamini G., Felkin, Leanne E., Dong, Jinrui, Cook, Stuart A, Yen, Paul M, Pakkiri, Leroy S, Shekeran, Shamini G, Chothani, Sonia P., Singh, Brijesh K, Adami, Eleonora, Zhou, Jin, Pakkiri, Leroy S., Hearn, Arron, Goh, Joyce, Singh, Brijesh K., Dear, James W, Drum, Chester Lee, Benjamin Ng, Sebastian Schafer, Brijesh K. Singh, Leroy S. Pakkiri, Chester L. Drum, Paul M. Yen, Stuart A. Cook, Sonia P. Chothani, Joyce Goh, Jessie Tan, Mao Wang, Shamini G. Shekeran, Wei Wen Lim, Sze Yun Lim, Leanne E. Felkin, Robert Holgate, James W. Dear, Jinrui Dong, Sivakumar Viswanathan, Jin Zhou, Anissa A. Widjaja, Arron Hearn, Eleonora Adami   +54 more
core   +1 more source

Human Illnesses and Animal Deaths Associated with Freshwater Harmful Algal Blooms—Kansas

Toxins, 2015
Freshwater harmful algal bloom (FHAB) toxins can cause morbidity and mortality in both humans and animals, and the incidence of FHABs in the United States and Kansas has increased. In 2010, the Kansas Department of Health and Environment (KDHE) developed
Ingrid Trevino-Garrison, Jamie DeMent, Farah S. Ahmed, Patricia Haines-Lieber, Thomas Langer, Henri Ménager, Janet Neff, Deon van der Merwe, Edward Carney   +8 more
doaj   +1 more source

Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin

Microorganisms, 2017
Nodularin (NOD) is a cyclic penta-peptide hepatotoxin mainly produced by Nodularia spumigena, reported from the brackish water bodies of various parts of the world.
Sultana Akter, Markus Vehniäinen, Harri T. Kankaanpää, Urpo Lamminmäki   +3 more
doaj   +1 more source